ArticleJournal of oral rehabilitation2026
Masticatory Dysfunction and Hippocampal Volume in Ageing Adults: An MRI-Based Scoping Review.
Article in Journal of oral rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreclinical studies show that experimental tooth extraction accelerates hippocampal degeneration, but the human neuroanatomical evidence has never been synthesised.
aimTo map and critically appraise structural MRI studies on associations between masticatory function and hippocampal/medial-temporal morphology in later life.
methodsA PRISMA-ScR-registered search (PubMed, Embase, Web of Science, Scopus, CINAHL; 1995-15 June 2025) targeted peer-reviewed studies of adults ≥ 60 years reporting quantitative masticatory indicators and in vivo structural neuroimaging outcomes including hippocampal or closely related medial-temporal metrics. Dual reviewers applied a PCC eligibility matrix, extracted data across five domains and appraised methodological quality using an eight-item JBI adaptation tailored to neuroimaging.
resultsEight studies published 2016-2024 (Japan = 4; Taiwan = 3; Sweden = 1) were included. Sample sizes ranged from 15 to 919 participants (median = 80). Six studies quantified dentition/tooth number, three applied objective chewing-performance tests and one used an occlusal-support composite (Eichner class). Five of six hippocampal/medial-temporal analyses reported significant inverse associations between poorer mastication and smaller hippocampal or parahippocampal measures, while one showed a concordant but non-significant trend. Dose-response gradients were evident in four datasets. In one population-based cohort, each 10-tooth decrement corresponded to approximately 2.2% lower bilateral hippocampal volume. In a study of cognitively impaired older adults, greater missing-tooth count was associated with smaller left hippocampal and parahippocampal GMV, whereas no corresponding association was detected in cognitively normal controls.
conclusionsCurrent structural MRI evidence in adults ≥ 60 years describes predominantly inverse associations between masticatory compromise and hippocampal/medial-temporal integrity; causality cannot be inferred. Longitudinal population-based neuroimaging using standardised chewing metrics, hippocampal subfield segmentation and rigorous adjustment for vascular, nutritional and inflammatory covariates is required to determine temporality and to test whether oral rehabilitation is associated with slower medial-temporal decline.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.