Evidence map›Paper›PMID 42253234›Full record

ArticleeLife2026

A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the

Steven A Calle-Schuler, Alexis Santana-Cruz, Lucia Kmecova, Stefanie Hampel, Andrew M Seeds

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Steven A Calle-Schuler *Institute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.ORCID https://orcid.org/0000-0003-1304-585X
Alexis Santana-Cruz *Institute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.ORCID https://orcid.org/0000-0002-8162-8072
Lucia KmecovaInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.ORCID https://orcid.org/0000-0003-2709-7562
Stefanie HampelInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.ORCID https://orcid.org/0000-0001-8287-549X
Andrew M SeedsInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.ORCID https://orcid.org/0000-0002-4932-6496

Funding

RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequenceRF1NS121911 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SEEDS, ANDREW MICHAEL · 2021 to 2021
$1.4M
High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequenceR01NS121911 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SEEDS, ANDREW MICHAEL · 2024 to 2025
$893k
BRAIN Initiative MH117815BRAIN Initiative R01NS121911National Science Foundation EES-1736019NIGMS NIH HHS P30-GM149367NIGMS NIH HHS R25GM061838NIMHD NIH HHS MD007600NINDS NIH HHS R01 NS121911NINDS NIH HHS RF1 NS121911Puerto Rico Science, Technology and Research Trust 2020-00195Whitehall Foundation 2017-12-69
6 · The paper itself

Abstract

Animals respond to tactile stimulations of the body with location-appropriate behavior, such as aimed grooming. These responses are mediated by mechanosensory neurons distributed across the body, whose axons project into somatotopically organized brain regions corresponding to body location. How mechanosensory neurons interface with brain circuits to transform mechanical stimulations into location-appropriate behavior is unclear. We previously described the somatotopic organization of bristle mechanosensory neurons (BMNs) around the

Indexed as

ConnectomeDrosophilaDrosophila melanogasterGroomingMechanoreceptorsAnimalsBrainHeadconnectomicsD. melanogasterDrosophila neurosciencegrooming behaviormechanosensationneurosciencesensorimotor circuitssomatotopy

Identifiers

PMID42253234
PMCPMC13246004

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.