Evidence map›Paper›PMID 42254080›Full record

ArticleJournal of nutrition and metabolism2026

Time-Restricted Feeding Preserves Synaptic Function and Modulates Reelin and

Zeynab Maleki, Mohammad Ali Mirshekar, Farzaneh Montazerifar, Bita Etminani, Fateme Keykha

Abstract read
In one paragraph

Article in Journal of nutrition and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zeynab MalekiStudent Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.
Mohammad Ali MirshekarClinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.ORCID https://orcid.org/0000-0002-0449-6440
Farzaneh MontazerifarDepartment of Food Sciences and Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.
Bita EtminaniStudent Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.
Fateme KeykhaStudent Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran, zaums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alzheimer's disease (AD), a major neurodegenerative disorder, is characterized by progressive cognitive decline and the accumulation of amyloid-beta and tau proteins in the brain. Intermittent fasting (IF) is being explored as a dietary intervention to mitigate AD-related effects, possibly by modulating factors such as reelin and Methods: The study included six groups of rats: Ctrl, Ctrl.ADF, Ctrl.TRF, AD, AD.TRF, and AD.ADF. AD was induced by bilateral ICV injections of 5 μL Aβ. To prove fasting, blood glucose levels were assessed with a glucometer. Memory and learning were assessed using the Morris Water Maze (MWM) test, and hippocampal reelin and Results: TRF was more effective than ADF in improving cognitive function in AD rats, as indicated by a significant increase in TSGQ [ Discussion: These findings suggest that TRF may enhance spatial memory and reduce

Indexed as

Alzheimer’s diseaseintermittent fastingratreelinα-synuclein

Identifiers

PMID42254080
PMCPMC13240393

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.