Evidence map›Paper›PMID 42255448›Full record

ArticleFrontiers in endocrinology2026

Therapeutic efficacy of glucocorticoids, ATP, and antithyroid drugs in acute thyrotoxic myopathy: evaluation using the acute thyrotoxic myopathy symptom score.

Qiaoli Li, Xuelan Chen, Zien Huang, Yun Zhang, Yaqi Kuang, Chunjiao Wu, Shien Fu, Tingliang Wang, Yuping Liu, Zhenxing Huang and 7 more

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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Qiaoli LiDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xuelan ChenDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zien HuangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yun ZhangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yaqi KuangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Chunjiao WuDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Shien FuDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Tingliang WangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yuping LiuDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhenxing HuangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Haiyan YangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jing XianDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Li LiDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jia ZhouDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xinghuan LiangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yingfen QinDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zuojie LuoDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute thyrotoxic myopathy (ATM) is a relatively rare and severe complication of hyperthyroidism, mainly reported in individual cases and lacking standardized treatment protocols. Objective: This study evaluated the efficacy of glucocorticoids (GCs), adenosine triphosphate (ATP), and antithyroid drugs (ATDs) in treating ATM to guide clinical management. Methods: We retrospectively analyzed 42 ATM patients treated with GCs, ATP, and ATDs. The Acute Thyrotoxic Myopathy Symptom Score (ATMSS) was applied to evaluate efficacy at baseline (T0), day 7 (T7), and day 28 (T28) of treatment. Binary logistic regression was used to identify predictors of therapeutic efficacy, examining the impact of pre-treatment biochemical indicators and ATMSS on symptom relief (R) at T7 and complete remission (CR) at T28. Result: ATMSS demonstrated significant improvement at both T7 and T28 ( Conclusion: The combination of GCs, ATP, and ATDs effectively alleviated the ATMSS in the short (7day) and medium (28day) term. However, recovery rates differ among symptoms. Specifically, dysarthria at baseline and muscle weakness at T7 showed significant predictive value for treatment outcomes.

Indexed as

Adenosine TriphosphateAntithyroid AgentsGlucocorticoidsMuscular DiseasesThyrotoxicosisAcute DiseaseAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexTreatment OutcomeAdenosine TriphosphateAntithyroid AgentsGlucocorticoidsacute thyrotoxic myopathyacute thyrotoxic myopathy symptom scoreadenosine triphosphateantithyroid drugsglucocorticoids

Identifiers

PMID42255448
PMCPMC13233379

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.