ArticleFood science & nutrition2026
Evaluating the Influence of Flaxseed Oil Against Docosahexaenoic Acid on Cancer Antigen CA15-3, Biochemical and Histopathological Parameters of DMBA-Induced Mammary Tumors Female Albino Wistar Rats.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The effect of flaxseed oil on the biochemical, CA15-3 markers and organs' microstructures of female rats with breast cancer induced using the 7,12-Dimethylbenz[a]anthracene (DMBA) against docosahexaenoic acid (DHA) was assessed. 36 female rats were used. Breast cancer was induced in 30 rats using the DMBA. At week 19, a total of 23 rats had developed tumors. Amongst them, 18 were selected and assembled in three groups of six rats each: The negative control to which was administered 250 mg/kg of distilled water, the positive control that received 125 mg/kg of DHA, the test group which was given 1000 mg/kg flaxseed oil and the normal group made of rats that were not induced but received 250 mg/kg of distilled water for 28 consecutive days. The rats were sacrificed and the blood collected to prepare the serum that was analyzed for the lipid profile, serum enzymes, breast cancer tumor marker, and creatinine levels. Histopathology of organs was done. Results showed that flaxseed oil and DHA increased the HDL and decreased the LDL, CA15-3, LDH, creatinine, AST and ALT compared to the negative control. Histopathological studies revealed protective properties of DHA and flaxseed oil on the organs.
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