Correlation Between Dietary Index for Gut Microbiota With All-Cause and Cardiovascular Mortality in Cardiovascular-Kidney-Metabolic Syndrome Patients.

The link between the dietary index for gut microbiota (DI-GM) and the risk of death in the Cardiovascular-Kidney-Metabolic Syndrome (CKM) population remains unclear. Our research investigates the relationship between DI-GM and mortality in CKM patients. Data from 13,562 individuals diagnosed with CKM, obtained from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2018, were analyzed. Kaplan-Meier curves, Cox regression, smooth curve fitting, and Subgroup analyses were applied to assess the link between DI-GM and mortality. During the average 82-months follow-up period, a total of 1236 deaths occurred, including 371 cases of cardiovascular death. Kaplan-Meier analysis showed that the lowest DI-GM group exhibited the highest rates of mortality. Multivariable Cox regression found that a one-point increase in the DI-GM score was associated with a 10% reduction in all-cause mortality risk and a 12% decrease in cardiovascular mortality risk. Smooth curve fitting and continuous dose-response estimates indicated a negative linear relationship between DI-GM scores and both all-cause and cardiovascular mortality, consistent across various subgroups. This research reveals that higher DI-GM concentrations in CKM syndrome patients correlate strongly with improved survival outcomes, especially for all-cause mortality and cardiovascular death among patients in CKM stages 0-3, while also showing significant benefits for all-cause mortality among patients in CKM stage 4.