Evidence map›Paper›PMID 42256294›Full record

ArticleiScience2026

Single-cell transcriptomics profiling elucidates RBP-driven metastatic signaling pathways in ER

Mingjie Dong, Xinyu Li, Songyu Yang, Shujuan Li, Zhengzheng Liu, Chuo Peng, Rongyao Li, Weixin Liang, Xia Li, Jing Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mingjie DongCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Xinyu LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Songyu YangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Shujuan LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Zhengzheng LiuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Chuo PengCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Rongyao LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Weixin LiangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Xia LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Jing BaiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estrogen receptor-positive breast cancer progression involves extensive cellular remodeling, yet the contribution of RNA-binding proteins to this process remains incompletely defined. Here, we constructed a single-cell transcriptomic atlas of 198,286 cells from 39 samples spanning normal tissue, primary tumors, and metastatic lesions. We identified stage-specific transcriptional and post-transcriptional reprogramming across different cell types. Several RBPs, including

Indexed as

biological sciences

Identifiers

PMID42256294
PMCPMC13233569

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.