Evidence map›Paper›PMID 42256296›Full record

ArticleiScience2026

Neural cues differentially modulate colorectal cancer cell behavior depending on patients' genomic background.

Meike S Thijssen, Rosaria Chilà, Giovanni Crisafulli, Kim M Smits, Alberto Bardelli, Werend Boesmans, Veerle Melotte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meike S ThijssenDepartment of Pathology, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, the Netherlands.
Rosaria ChilàIFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.
Giovanni CrisafulliIFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.
Kim M SmitsDepartment of Pathology, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, the Netherlands.
Alberto BardelliIFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy.
Werend BoesmansDepartment of Pathology, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, the Netherlands.
Veerle MelotteDepartment of Pathology, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center, Maastricht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While neurons are mostly described as pro-tumorigenic and linked with a poor prognosis, differing outcomes have been reported for colorectal cancer (CRC) due to the lack of control for neural and patient subtype diversity. In this study, we investigated the effect of neural cues on patient-derived CRC cell lines selected based on genomic status, e.g., microsatellite instability (MSI) and

Indexed as

microenvironmentneuroscienceoncology

Identifiers

PMID42256296
PMCPMC13233565

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.