ArticleHemaSphere2026
Prognostic value of measurable residual disease in high-risk MDS after intensive chemotherapy in HOVON-SAKK studies.
Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
27 authors.
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Abstract
Myelodysplastic syndromes (MDS) are heterogenous disorders in which response assessment remains challenging. In acute myeloid leukemia (AML), measurable residual disease (MRD) by multiparametric flow cytometry (MFC) is prognostic and guides decision-making after two cycles of intensive chemotherapy, but its role in high-risk MDS (hrMDS) is unknown. We aimed to determine the prognostic impact of MFC-MRD (0.1% cutoff) for overall survival (OS) and the cumulative incidence of relapse (CIR) in intensively treated hrMDS. After stringent selection from 3269 patients enrolled in prior HOVON-SAKK MDS/AML trials, we identified 91 ICC 2022-defined hrMDS patients with available MFC-MRD. MFC-MRD positivity was detected in 24% and associated with inferior survival (5-year OS: 22.7% vs. 43.7%; P = 0.010) and higher relapse risk (5-year CIR: 72.7% vs. 47.2%; P = 0.014). In multivariable analyses stratified by trial and adjusted for, among others, the presence of a biallelic
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Registered trials
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