Evidence map›Paper›PMID 42256806›Full record

ReviewJournal of orthopaedic translation2026

CEST MRI: Translational prospects for intervertebral disc degeneration - from basic research to clinical applications.

Renchang Chen, Hao Wang, Yutong Li, Gang Zhang, Xin Zhang, Xintian Qu, Wenzhe Bai, Zhichao Li, Yadong Wu, Songlin Liang and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Renchang ChenThe First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Hao WangThe First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Yutong LiSchool of Engineering and Applied Science, University of Pennsylvania, Commonwealth of Pennsylvania, USA.
Gang ZhangThe First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xin ZhangWeifang Hospital of Traditional Chinese Medicine, Weifang, China.
Xintian QuThe First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Wenzhe BaiThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Zhichao LiThe First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Yadong WuThe First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Songlin LiangThe First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Moji WangchenThe First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Nianhu LiThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Peng KongThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Xu WeiWangjing Hospital of China Academy of Chinese Medical Sciences, Peking, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low back pain (LBP) caused by intervertebral disc degeneration (IVDD) is characterized by metabolic and biochemical alterations within the intervertebral disc (IVD) microenvironment. Conventional magnetic resonance imaging (MRI) is limited in its ability to accurately evaluate and precisely quantify changes these small-molecule changes. Chemical exchange saturation transfer (CEST) is an emerging MRI modality that exploits exchangeable protons (such as-OH, -NH, and -NH Translational potential statement: CEST generates specific molecular imaging contrast in tissues rich in exchangeable protons with suitable water exchange rates. It offers a distinct advantage in non-invasively quantifying

Indexed as

Artificial intelligenceChemical exchange saturation transferGlycosaminoglycanIntervertebral disc degenerationLow back painpH value

Identifiers

PMID42256806
PMCPMC13233771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.