Prophylactic Proton Pump Inhibitors in Critically Ill Patients Undergoing Invasive Ventilation: A Systematic Review and Meta-Analysis of Randomized Trials.

Jinlu Hu, Haiyan Ye, Bo Li, Xuemei Zheng

Abstract read

In one paragraph

Article in Critical care research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Prophylactic Proton Pump Inhibitors in Critically Ill Patients Undergoing Invasive Ventilation: A Systematic Review and Meta-Analysis of Randomized Trials.Critical care research and practice · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jinlu HuDepartment of Adult Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China, uestc.edu.cn.ORCID https://orcid.org/0009-0001-0509-7767

Haiyan YeDepartment of Adult Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China, uestc.edu.cn.ORCID https://orcid.org/0009-0004-9462-1066

Bo LiDepartment of Adult Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China, uestc.edu.cn.ORCID https://orcid.org/0009-0009-2789-4271

Xuemei ZhengDepartment of Adult Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China, uestc.edu.cn.ORCID https://orcid.org/0000-0002-5380-5457

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To assess the safety and efficacy of prophylactic proton pump inhibitors (PPIs) among critically ill adults undergoing invasive ventilation. Methods: We systematically searched PubMed, Web of Science, Embase, and the Cochrane Library for randomized controlled trials (RCTs) published up to September 19, 2024. Eligible trials compared prophylactic PPIs with placebo or no prophylaxis for upper gastrointestinal bleeding (UGIB) prevention in adults receiving invasive ventilation. Nine RCTs encompassing 8388 patients were included. Data were pooled using Review Manager 5.4, with a random-effects model applied to all outcomes. Results: All-cause mortality rates were comparable between the PPI and control groups (odds ratio [OR]: 0.98; 95% confidence interval [CI]: 0.89-1.07; I Conclusion: Among mechanically ventilated patients, prophylactic PPI therapy significantly decreased UGIB and clinically important UGIB risk compared to placebo, without affecting all-cause mortality.

Indexed as

Clostridioides difficile infectioncritically illinvasive ventilationproton pump inhibitorsupper gastrointestinal bleedingventilator-associated pneumonia

Identifiers

PMID42256809

DOI10.1155/ccrp/5581019

PMCPMC13238534

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.