Evidence map›Paper›PMID 42257379›Full record

ArticleJournal of agricultural and food chemistry2026

Neoagarotetraose from Marine Red Algae Attenuates Hypertensive Vascular Remodeling by Targeting FoxO4 to Inhibit Mitochondrial Superoxide Generation.

Nan Wu, Chaocheng Wu, Yating Du, Zhuhua Chan, Runying Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nan WuTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen361005, China.ORCID 0000-0001-5594-5042
Chaocheng WuTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen361005, China.
Yating DuTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen361005, China.
Zhuhua ChanTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen361005, China.
Runying ZengTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen361005, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is a key driver of hypertensive vascular remodeling. Neoagarotetraose (NA4), a marine-derived oligosaccharide, possesses potent antioxidant activity, but its effects on hypertension remain unexplored. Here, we investigated the role of NA4 in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR) and in SHR in vivo. NA4 treatment significantly reduced mitochondrial superoxide, H

Indexed as

Forkhead Transcription FactorsHypertensionMitochondriaOligosaccharidesSuperoxidesTranscription FactorsVascular RemodelingAnimalsHumansHydrogen PeroxideMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleOxidative StressRatsRats, Inbred SHRForkhead Transcription FactorsFOXO4 protein, ratHydrogen PeroxideOligosaccharidesSuperoxidesTranscription FactorsFoxO4hypertensionmitochondrial oxidative stressneoagarotetraose (NA4)vascular remodeling

Identifiers

PMID42257379
PMCPMC13281518

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.