Evidence map›Paper›PMID 42257976›Full record

ReviewApoptosis : an international journal on programmed cell death2026

Targeting programmed cell death: a novel therapeutic paradigm for cancer based on mode-of-death classification.

Xi Qiao, Ting Ye, Tinggai Wu, Xu Han, Tiantian Sun, Haiqiang Wang, Junru Jia, Yuanyuan Dai, Ruohan Yun, Shuo Jiang and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xi Qiao *Henan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Ting Ye *Henan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Tinggai Wu *Henan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Xu HanHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Tiantian SunHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Haiqiang WangHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Junru JiaHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Yuanyuan DaiHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Ruohan YunHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Shuo JiangHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Yuming QinHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Zhenzhen LiuHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Yang AnHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China. anyang@henu.edu.cn.
Xinying JiHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China. 10190096@vip.henu.edu.cn.
Shuangyu LvHenan International Joint Laboratory of Nuclear Protein Regulation, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China. shuangyulv@henu.edu.cn.

Funding

Henan Provincial Science Popularization Expert Studio No.HNKP2026091the China Postdoctoral Science Function No. 2024M750782the Cultivation Project for Innovation Team in Teachers' Teaching Proficiency by Zhengzhou Health College No. 2024jxcxtd01the Innovation Project for College Students of Henan University No. 202510475073, 202510475143, 202510475139, 20253201155, 20253201192, 20253305189the Medical Science and Technology Program of Henan Province No. JQRC2025017the Program for Innovative Talents of Science and Technology in Henan Province No. 23HASTIT043
6 · The paper itself

Abstract

Programmed cell death (PCD) refers to a form of cell death governed by genetic regulation, and consists of several distinct pathways, including apoptosis, autophagy, cuproptosis, ferroptosis, necroptosis, paraptosis and pyroptosis. These pathways are crucial for maintaining intracellular stability and homeostasis, which are involved in the pathogenesis of various diseases. This review innovatively proposes an integrated framework classified by death patterns, and systematically expounds the strategic significance of targeting PCD in cancer treatment. Based on this framework, we conduct an in-depth analysis of how to design corresponding therapeutic strategies for different death patterns, with a particular emphasis on the complex cross-talk and synergistic effects among different PCD pathways. Moreover, we demonstrate that this interaction is the cornerstone for designing the next generation of combination treatment regimens. The aim is to lay a foundation and point out the future direction for the development of more effective and targeted cancer treatment strategies based on the regulation of PCD networks.

Indexed as

ApoptosisNeoplasmsAnimalsAntineoplastic AgentsAutophagyCuproptosisFerroptosisHumansNecroptosisParaptosisPyroptosisSignal TransductionAntineoplastic AgentsApoptosisAutophagyCancerProgrammed cell deathPyroptosis

Identifiers

PMID42257976

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.