ArticleScience China. Life sciences2026
E-Syt1 recruits PI4KA to endoplasmic reticulum-plasma membrane junctions to enhance PI4P synthesis.
Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Phosphatidylinositol-4-phosphate (PI4P) is a low-abundance membrane lipid that plays crucial roles in lipid exchange and homeostasis, signal transduction, and vesicle trafficking. PI4KA, a type III phosphatidylinositol 4-kinase, catalyzes PI4P synthesis at the plasma membrane (PM). However, the mechanism by which cytoplasmic PI4KA is recruited to the PM to regulate PI4P levels in response to extracellular and intracellular signals remains unclear. We found that PI4KA is tightly associated with membranous organelles, including the endoplasmic reticulum (ER). In response to Ca
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