Evidence map›Paper›PMID 42258258›Full record

Trial reportExperimental and clinical psychopharmacology2026

Effects of the neuroactive steroid precursor pregnenolone on stress- and alcohol cue-provoked pain responses in individuals with alcohol use disorder.

Riley Quinlan, Huaze Gao, Rajita Sinha, Verica Milivojevic

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental and clinical psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Riley QuinlanDepartment of Psychiatry, Yale Stress Center, Yale University School of Medicine.
Huaze GaoDepartment of Psychiatry, Yale Stress Center, Yale University School of Medicine.
Rajita SinhaDepartment of Psychiatry, Yale Stress Center, Yale University School of Medicine.
Verica MilivojevicDepartment of Psychiatry, Yale Stress Center, Yale University School of Medicine.ORCID 0000-0001-6752-2223

Funding

Pregnenolone for the Treatment of Alcohol Use DisorderR01AA030923 · NIAAA · YALE UNIVERSITY · PI VERICA MILIVOJEVIC, Rajita Sinha · 2023 to 2026
$2.9M
Neuroactive Steroid Potentiation to Decrease Alcohol Craving, Normalize HPA axis function and Prevent Alcohol RelapseR01AA026514 · NIAAA · YALE UNIVERSITY · PI SINHA, RAJITA · 2018 to 2021
$2.8M
The role of neuroactive steroids in stress, drug craving and drug use in cocaine use disordersK01DA046561 · NIDA · YALE UNIVERSITY · PI MILIVOJEVIC, VERICA · 2019 to 2023
$913k
National Institutes of Health; National Institute on Alcohol Abuse and AlcoholismNational Institutes of Health; National Institute on Drug AbuseNIAAA NIH HHS R01 AA026514NIAAA NIH HHS R01 AA030923NIDA NIH HHS K01 DA046561
6 · The paper itself

Abstract

Chronic alcohol use reduces GABAergic activity and neuroactive steroid levels, contributing to stress response dysregulation and heightened pain sensitivity in individuals with alcohol use disorder (AUD). Neuroactive steroid precursor pregnenolone (PREG) reduces stress- and cue-related craving and anxiety responses in individuals with AUD, but its effects on pain responses in AUD have not been assessed. Sixty treatment-seeking men and women with AUD in an 8-week randomized trial receiving placebo (PBO;

Indexed as

AlcoholismPainPregnenoloneStress, PsychologicalAdultAnxietyCravingCuesFemaleHumansMaleMiddle AgedPain MeasurementPregnenolone

Identifiers

PMID42258258
PMCPMC13251320

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.