Evidence map›Paper›PMID 42258342›Full record

ArticleAmerican journal of physiology. Cell physiology2026

Transcriptomics reveal dysregulated genes during folic acid-induced acute injury and fibrosis in kidney and their attenuation by antioxidant

Ramji Kandel, Priti Roy, Irfan Warraich, Kamaleshwar P Singh

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ramji KandelDepartment of Environmental Toxicology, Texas Tech University, Lubbock, Texas, United States.ORCID 0000-0001-9180-8088
Priti RoyDepartment of Environmental Toxicology, Texas Tech University, Lubbock, Texas, United States.
Irfan WarraichDepartment of Pathology, Texas Tech University Health Science Center, School of Medicine, Lubbock, Texas, United States.
Kamaleshwar P SinghDepartment of Environmental Toxicology, Texas Tech University, Lubbock, Texas, United States.ORCID 0000-0002-5731-6781

Funding

Targeting oxidative stress-induced epigenetic reprogramming in fibrotic diseaseR15DK121362 · NIDDK · TEXAS TECH UNIVERSITY · PI SINGH, KAMALESHWAR P · 2021 to 2022
$808k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R15DK121362-01A1NIDDK NIH HHS R15 DK121362
6 · The paper itself

Abstract

Renal fibrosis is a common pathogenic stage during the progression of acute injury to chronic kidney disease. Pathophysiological changes such as cellular remodeling, dysregulation of fibrogenic signaling, and extracellular matrix contribute to kidney fibrosis. Oxidative stress is a common feature of nephrotoxicants. However, the target molecules and mechanistic pathways dysregulated by oxidative stress during acute injury and fibrosis in kidney are not fully understood. Therefore, the objective of this study was to identify the target molecules altered by oxidative stress and determine whether the antioxidant

Indexed as

AcetylcysteineAcute Kidney InjuryAntioxidantsFolic AcidKidneyTranscriptomeAnimalsFibrosisGene Expression ProfilingHumansMaleMiceMice, Inbred C57BLOxidative StressSignal TransductionAcetylcysteineAntioxidantsFolic Acidacute kidney injuryantioxidantsfolic acidkidney fibrosisoxidative stress

Identifiers

PMID42258342
PMCPMC13383868

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.