Exosome Nanotherapy Rescues Male Fertility by Delivering Integrin β1 to Repair Environmental Stress-Damaged Testes.

Jiahua Meng, Jingyue Wang, Zengfeng Li, Fei Li, Xiang Yun, Yulan Jin, Lin Zhang

Abstract read

In one paragraph

Article in Molecular pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiahua MengSchool of Public Health, North China University of Science and technology, Tangshan 063200, China.

Jingyue WangSchool of Public Health, North China University of Science and technology, Tangshan 063200, China.

Zengfeng LiSchool of Public Health, North China University of Science and technology, Tangshan 063200, China.

Fei LiSchool of Public Health, North China University of Science and technology, Tangshan 063200, China.

Xiang YunSchool of Public Health, North China University of Science and technology, Tangshan 063200, China.

Yulan JinSchool of Public Health, North China University of Science and technology, Tangshan 063200, China.

Lin ZhangClinical Research Center for Obstetrics and Gynecology, Key Laboratory of Maternal & Fetal Medicine of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250001, China.ORCID 0000-0002-5269-9728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental thermal-mechanical (T&M) stress threatens male fertility globally, yet no molecular therapies exist for stress-induced testicular damage. We demonstrate that macrophage-derived exosomes (Mφ-EVs) function as precision nanomedicines restoring fertility by delivering Integrin β1 (ITGB1) to repair damaged spermatogenic cytoskeletons. Using validated T&M stress models in C57BL/6 mice and GC-2 spermatocytes, we characterized severe reproductive dysfunction: 14.4% motility reduction (83.0 ± 2.0% to 71.3 ± 1.7%), 69.2% increased abnormalities (8.7 ± 2.3% to 14.7 ± 2.3%), and disrupted cytoskeletal homeostasis with Layilin (2.87-fold), Talin (3.90-fold), and Vinculin (4.24-fold) upregulation (

Indexed as

ExosomesFertilityInfertility, MaleIntegrin beta1TestisAnimalsCytoskeletonMacrophagesMaleMiceMice, Inbred C57BLSpermatocytesSpermatogenesisIntegrin beta1Itgb1 protein, mouseCytoskeletal remodelingIntegrin β1Macrophage-derived exosomeMale infertilityThermal-mechanical stress

Identifiers

PMID42258346

DOI10.1021/acs.molpharmaceut.6c00656

PMCPMC13344300

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.