Evidence map›Paper›PMID 42259287›Full record

ArticleNeuron2026

Methamphetamine potentiates the use of outcome-specific associations via a hypothalamic-dopamine circuit.

Ivy B Hoang, Joseph J Munier, Anna Verghese, Masakazu Taira, Arvie R Abiero, Jessica Leake, Adrian Dawson, Mirari Wilcher, Kiruthika Ganesan, Miriam E Ortega and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ivy B HoangDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: ihoang@ucla.edu.
Joseph J MunierSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA.
Anna VergheseDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Masakazu TairaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychology, University of Sydney, Camperdown, NSW, Australia.
Arvie R AbieroDepartment of Psychology, University of Sydney, Camperdown, NSW, Australia.
Jessica LeakeDepartment of Psychology, University of Sydney, Camperdown, NSW, Australia.
Adrian DawsonDepartment of Psychology, University of Sydney, Camperdown, NSW, Australia.
Mirari WilcherDepartment of Psychology, University of Sydney, Camperdown, NSW, Australia.
Kiruthika GanesanDepartment of Psychology, University of Sydney, Camperdown, NSW, Australia.
Miriam E OrtegaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Vanessa ReyesDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Zara GreerDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Samuel J MillardDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Lauren E DiFazioDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Courtney SercanderNational Institute on Drug Abuse, Baltimore, MD, USA.
Elena BagleySchool of Pharmacy, University of Sydney, Camperdown, NSW, Australia.
Bryony WintersSchool of Pharmacy, University of Sydney, Camperdown, NSW, Australia.
Alicia IzquierdoDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Melissa J SharpeDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychology, University of Sydney, Camperdown, NSW, Australia. Electronic address: melissa.sharpe@sydney.edu.au.

Funding

UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
Contribution of non-canonical dopamine pathways to model-based learningR01DA057084 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Melissa Sharpe, Kate M Wassum · 2023 to 2026
$2.5M
The role of the lateral hypothalamus in the balance of learning and behavior towards relevant stimuliR01DA054967 · NIDA · UNIVERSITY OF SYDNEY · PI Melissa Sharpe · 2022 to 2026
$1.5M
Investigating the Recruitment of Lateral Hypothalamic Circuits for Encoding Fear Memories Following Experience with Reward LearningR21MH126278 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHARPE, MELISSA · 2022 to 2023
$429k
Sex differences in neuroendocrine mechanisms of HPA axis dysfunction in alcohol use disorderF31AA028183 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MUNIER, JOSEPH · 2020 to 2021
$75k
NIAAA NIH HHS F31 AA028183NIDA NIH HHS R01 DA054967NIDA NIH HHS R01 DA057084NIDA NIH HHS T32 DA024635NIMH NIH HHS R21 MH126278
6 · The paper itself

Abstract

Drug cues strongly influence drug seeking and relapse to addiction. However, it is unclear how drug cues do this. We reveal that a novel pathway from ventral tegmental area dopamine (VTA

Indexed as

dopaminedrug addictionlateral hypothalamusmethamphetaminereward learning

Identifiers

PMID42259287
PMCPMC13251330

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.