Evidence map›Paper›PMID 42259820›Full record

ArticleNature communications2026

Ultrastructural diversity and subcellular organization of nigral Lewy pathology in Parkinson's disease.

Amanda J Lewis, Lukas van den Heuvel, Marta Di Fabrizio, Kaliya Bandelier, Daria Proniakova, Domenic Burger, Notash Shafiei, Kazadi Ekundayo, Selene Offringa, Evelien Huisman and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amanda J LewisLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland. amanda.lewis@epfl.ch.ORCID http://orcid.org/0000-0001-7257-5848
Lukas van den HeuvelLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-9168-8450
Marta Di FabrizioLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Kaliya BandelierLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Daria ProniakovaLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Domenic BurgerLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Notash ShafieiLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0009-0005-4567-9795
Kazadi EkundayoLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0009-0003-1824-0037
Selene OffringaLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0009-0009-1148-2707
Evelien HuismanDepartment of Anatomy and Neurosciences, section Clinical Neuroanatomy and Biobanking, Amsterdam Neuroscience, Amsterdam University Medical Centre, Vrije University Amsterdam, Amsterdam, The Netherlands.
John Gjm BolDepartment of Anatomy and Neurosciences, section Clinical Neuroanatomy and Biobanking, Amsterdam Neuroscience, Amsterdam University Medical Centre, Vrije University Amsterdam, Amsterdam, The Netherlands.
Wilma Dj van de BergDepartment of Anatomy and Neurosciences, section Clinical Neuroanatomy and Biobanking, Amsterdam Neuroscience, Amsterdam University Medical Centre, Vrije University Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6175-5357
Henning StahlbergLaboratory of Biological Electron Microscopy, School of Basic Sciences, Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-1185-4592

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) No. 101118656Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_188548Stiftung Synapsis - Alzheimer Forschung Schweiz AFS (Synapsis Foundation - Alzheimer Research Switzerland) 2019-CDA01
6 · The paper itself

Abstract

Lewy bodies, the defining pathological feature of Parkinson's disease, are intraneuronal inclusions enriched in aggregated alpha-synuclein (αSyn). We used correlative light and electron microscopy to selectively investigate phosphorylated αSyn (αSyn

Indexed as

Lewy BodiesParkinson DiseaseSubstantia NigraAgedalpha-SynucleinDopaminergic NeuronsFemaleHumansMalePhosphorylationalpha-Synuclein

Identifiers

PMID42259820
PMCPMC13396239

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.