Evidence map›Paper›PMID 42259845›Full record

ArticleScientific reports2026

A novel method for standardised imaging of corneal subbasal nerves by in vivo confocal microscopy - a pilot validation study.

Siv A Sandvik, Eilin Lundanes, Stephan Allgeier, Emanuele Käser, Neil Lagali, Jorunn Lid, Tove Lise Morisbakk, Vibeke Sundling

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siv A SandvikNational Centre for Optics, Vision and Eye Care, Department of Optometry, Radiography and Lighting Design, University of South-Eastern Norway, Postbox 4, Borre, 3199, Norway. sivasandvik@gmail.com.
Eilin LundanesNational Centre for Optics, Vision and Eye Care, Department of Optometry, Radiography and Lighting Design, University of South-Eastern Norway, Postbox 4, Borre, 3199, Norway.
Stephan AllgeierInstitute for Automation and Applied Informatics, Karlsruhe Institute of Technology (KIT), Postfach 3640, 76021, Karlsruhe, Germany.
Emanuele KäserInstitute of Optometry, University of Applied Sciences and Arts Northwestern Switzerland FHNW, Olten, 4600, Switzerland.
Neil LagaliDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, SE-581 83, Sweden.
Jorunn LidNational Centre for Optics, Vision and Eye Care, Department of Optometry, Radiography and Lighting Design, University of South-Eastern Norway, Postbox 4, Borre, 3199, Norway.
Tove Lise MorisbakkNational Centre for Optics, Vision and Eye Care, Department of Optometry, Radiography and Lighting Design, University of South-Eastern Norway, Postbox 4, Borre, 3199, Norway.
Vibeke SundlingNational Centre for Optics, Vision and Eye Care, Department of Optometry, Radiography and Lighting Design, University of South-Eastern Norway, Postbox 4, Borre, 3199, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vivo confocal microscopy is a valuable tool for evaluating corneal subbasal nerve plexus (SBNP). However, lack of standardised, repeatable, and reliable methods is a challenge, particularly in clinical, multi-centre, and longitudinal settings. To address this, we developed a standardised imaging method using the inferior whorl (IW) region of the SBNP as a reference for imaging a predefined 1.5 mm

Indexed as

CorneaHumansMicroscopy, ConfocalPilot ProjectsReproducibility of ResultsCorneaImaging methodInferior whorlIn vivo confocal microscopyNerve fibres

Identifiers

PMID42259845
PMCPMC13385856

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.