Evidence map›Paper›PMID 42259917›Full record

ArticleNature2026

Distributed control circuits across a brain-and-cord connectome.

Alexander S Bates, Jasper S Phelps, Minsu Kim, Helen H Yang, Arie Matsliah, Zaki Ajabi, Eric Perlman, Kevin M Delgado, Mohammed Abdal Monium Osman, Christopher K Salmon and 91 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
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  6. Uncovering Sex Differences in thebioRxiv : the preprint server for biology · 2026
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  10. The digital sphinx: Can a worm brain control a fly body?bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Glutamate receptor composition atbioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Article
  16. Connectomic mapping of pharyngeal and gut sensory circuits in adultbioRxiv : the preprint server for biology · 2025
    Article
  17. Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

101 authors.

Alexander S Bates *Department of Neurobiology, Harvard Medical School, Boston, MA, USA. Alexander_Bates@hms.harvard.edu.ORCID http://orcid.org/0000-0002-1195-0445
Jasper S Phelps *Department of Neurobiology, Harvard Medical School, Boston, MA, USA. jasper.s.phelps@gmail.com.ORCID http://orcid.org/0000-0001-8033-258X
Minsu Kim *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0074-6684
Helen H Yang *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Arie MatsliahPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0009-0001-4490-2028
Zaki AjabiDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4411-4005
Eric PerlmanYikes, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5542-1302
Kevin M DelgadoDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Mohammed Abdal Monium OsmanDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Christopher K SalmonPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Jay GagerPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-8001-2604
Benjamin SilvermanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Sophia RenauldDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Farzaan SalmanDepartment of Biology, West Virginia University, Morgantown, WV, USA.
Janki PatelDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Matthew F CollieDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Jingxuan FanDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7860-4558
Diego A PachecoDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1638-2376
Yunzhi ZhaoDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Wenyi ZhangDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Laia Serratosa CapdevilaAelysia, Bristol, UK.
Ruairí J V RobertsAelysia, Bristol, UK.
Eva J MunnellyAelysia, Bristol, UK.
Nina GriggsAelysia, Bristol, UK.
Helen LangleyAelysia, Bristol, UK.
Borja Moya-LlamasAelysia, Bristol, UK.
Zuoyu ZhangBeijing Institute for Brain Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0009-0009-6679-4396
Ryan T MaloneyDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6111-7822
Szi-Chieh YuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0009-0001-9684-0156
Amy R SterlingPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-4961-3954
Marissa SorekPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Krzysztof KrukEyewire, Boston, MA, USA.ORCID http://orcid.org/0009-0005-9305-7042
Nikitas SerafetinidisEyewire, Boston, MA, USA.
Serene DhawanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Finja KlemmGenetics Department, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0009-0005-3800-3244
Paul BrooksZoology Department, University of Cambridge, Cambridge, UK.
Ellen LesserDepartment of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, USA.
Jessica M JonesDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3638-255X
Sara E Pierce-LundgrenDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0009-4589-761X
Su-Yee LeeDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.
Yichen LuoDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2265-1117
Andrew P CookSchool of Neuroscience, Virginia Tech, Blacksburg, VA, USA.
Theresa H McKimDepartment of Biology, University of Nevada Reno, Reno, NV, USA.ORCID http://orcid.org/0000-0002-8501-6487
Dimitrios Stasi GiakoumasDepartment of Biology, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0009-0006-8602-2308
Benjamin GorkoMolecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0003-4341-6455
Justin Ellis-JoyceHHMI Janelia, Ashburn, VA, USA.
Jiayi ZhangInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Emily C KophsDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0009-0006-6287-7205
Tjalda FaltMax Planck Institute for Biological Intelligence, Martinsried, Germany.
Alexa M Negron-MoralesInstitute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Austin BurkePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
James HebditchPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Kyle P WilliePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Ryan WilliePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Sergiy PopovychZetta AI, Sherrill, NY, USA.
Nico KemnitzZetta AI, Sherrill, NY, USA.
Dodam IhZetta AI, Sherrill, NY, USA.
Kisuk LeeZetta AI, Sherrill, NY, USA.
Ran LuZetta AI, Sherrill, NY, USA.
Akhilesh HalageriZetta AI, Sherrill, NY, USA.
J Alexander BaeZetta AI, Sherrill, NY, USA.
Ben JourdanSchool of Informatics, University of Edinburgh, Edinburgh, UK.
Gregory SchwartzmanJapan Advanced Institute of Science and Technology (JAIST), Nomi, Japan.
Damian D DemarestMolecular Brain Physiology and Behavior, LIMES Institute, University of Bonn, Bonn, Germany.
Emily BehnkePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Doug BlandEyewire, Boston, MA, USA.
Anne KristiansenEyewire, Boston, MA, USA.
Jaime SkeltonEyewire, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5097-3834
Tom StocksEyewire, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0290-1630
Dustin GarnerMolecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0009-0007-4344-4989
Anthony HernandezEyewire, Boston, MA, USA.
Sandeep KumarPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0001-7181-232X
BANC-FlyWire Consortium
Kevin C DalyDepartment of Biology, West Virginia University, Morgantown, WV, USA.
Sven DorkenwaldAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2352-319X
Forrest CollmanAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0280-7022
Marie P SuverDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4491-6996
Lisa M FenkMax Planck Institute for Biological Intelligence, Martinsried, Germany.
Michael J PankratzMolecular Brain Physiology and Behavior, LIMES Institute, University of Bonn, Bonn, Germany.
Zepeng YaoDepartment of Biology, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-0186-5503
Fei WangInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Stephen J HustonDepartment of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-0834-3257
Tomke StürnerNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0003-4054-0784
Gregory S X E JefferisZoology Department, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0587-9355
Katharina EichlerGenetics Department, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0000-0002-7833-8621
Andrew M SeedsInstitute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.ORCID http://orcid.org/0000-0002-4932-6496
Stefanie HampelInstitute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Sweta AgrawalSchool of Neuroscience, Virginia Tech, Blacksburg, VA, USA.ORCID http://orcid.org/0000-0003-0547-4099
Tatsuo S OkuboBeijing Institute for Brain Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Meet ZandawalaDepartment of Biochemistry and Molecular Biology, University of Nevada Reno, Reno, NV, USA.ORCID http://orcid.org/0000-0001-6498-2208
Thomas MacrinaZetta AI, Sherrill, NY, USA.ORCID http://orcid.org/0000-0002-0622-9338
Diane-Yayra AdjavonHHMI Janelia, Ashburn, VA, USA.
Jan FunkeHHMI Janelia, Ashburn, VA, USA.ORCID http://orcid.org/0000-0003-4388-7783
John C TuthillDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5689-5806
Anthony AzevedoDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8318-9678
H Sebastian SeungPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-8591-6733
Benjamin L de BivortDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6165-7696
Mala MurthyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA. mmurthy@princeton.edu.ORCID http://orcid.org/0000-0003-3063-3389
Jan DrugowitschDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. jan_drugowitsch@hms.harvard.edu.ORCID http://orcid.org/0000-0002-7846-0408
Rachel I WilsonDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. rachel_wilson@hms.harvard.edu.ORCID http://orcid.org/0000-0001-8573-9266
Wei-Chung Allen LeeDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. wei-chung_lee@hms.harvard.edu.ORCID http://orcid.org/0000-0002-4618-295X

Funding

Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Structural Variation in Neuronal Circuits as a Basis for Functional and Behavioral IndividualityR01NS121874 · NINDS · HARVARD MEDICAL SCHOOL · PI DE BIVORT, BENJAMIN, HASSAN, BASSEM A · 2021 to 2025
$5.0M
Tools to broaden access to high-throughput functional connectomicsRF1MH117808 · NIMH · HARVARD MEDICAL SCHOOL · PI LEE, WEI-CHUNG ALLEN, MACRINA, THOMAS · 2019 to 2019
$4.3M
Accelerating connectomic proofreading for larger brains and multiple individualsRF1MH129268 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA · 2022 to 2022
$2.1M
High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequenceR01NS121911 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SEEDS, ANDREW MICHAEL · 2024 to 2025
$893k
NIGMS NIH HHS T32 GM144273NIMH NIH HHS RF1 MH117808NIMH NIH HHS RF1 MH129268NINDS NIH HHS R01 NS121874NINDS NIH HHS R01 NS121911NINDS NIH HHS U24 NS126935
6 · The paper itself

Abstract

Just as genomes revolutionized molecular genetics, connectomes (maps of neurons and synapses) are transforming neuroscience. To date, the only organisms with complete connectomes are worms

Indexed as

ConnectomeDrosophila melanogasterNeural PathwaysAnimalsBrainEndocrine CellsFemaleMaleMotor NeuronsNeuronsNeurons, EfferentSensory Receptor CellsSynapses

Identifiers

PMID42259917
PMCPMC13518251

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.