ReviewNature cardiovascular research2026
Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease.
Review in Nature cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increasing concern in healthcare is the co-occurrence of mental and somatic disorders in patients, illustrated most prominently by the comorbidity of anxiety and mood disorders (AMD) with cardiovascular disease (CVD). Here we show that this comorbidity is largely mediated by genetic and environmental effects on risk mechanisms from the biological, behavioral, psychological and social domains shared by AMD and CVD. Genetically informative designs support the causal effects of AMD on the risk of CVD but show no evidence of reverse causality. This aligns with meta-analyses of randomized controlled trials that support positive effects of AMD treatment on CVD but find no consistent effects in the opposite direction. We suggest that patients with both CVD and AMD would benefit from a collaborative care approach. Interventions should focus on modifiable shared risk factors for both conditions, with lifestyle improvement and stress management appearing most promising.
Indexed as
Identifiers
42259986What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.