Evidence mapPaperPMID 42260139Full record

ReviewJournal of neurology2026

Clinical telemonitoring and telerehabilitation of cognition in rare neurological diseases: a scoping review.

Michelangelo Dini, Elisabetta Maida, Luigi Lavorgna, Annemieke Buizer, Alessandra Fanciulli, Kadri Medijainen, Jorik Nonnekes, Juan Dario Ortigoza-Escobar, Andras Salamon, Dagmar Timmann and 3 more

Abstract readScoping ReviewReview
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In one paragraph

Review in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michelangelo DiniFaculty of Psychology, Vita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0002-2430-8902
Elisabetta MaidaDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Luigi LavorgnaDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Annemieke BuizerDepartment of Rehabilitation Medicine and Emma Children's Hospital, Amsterdam UMC, Amsterdam Movement Sciences, Rehabilitation and Development, Amsterdam, The Netherlands.
Alessandra FanciulliDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Kadri MedijainenInstitute of Sport Sciences and Physiotherapy, University of Tartu, Tartu, Estonia.
Jorik NonnekesDonders Institute for Brain, Cognition and Behaviour, Department of Rehabilitation, Centre of Expertise for Parkinson and Movement Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.
Juan Dario Ortigoza-EscobarMovement Diseases Unit, Pediatric Neurology Department, Institut de Recerca, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.
Andras SalamonDepartment of Neurology, University of Szeged, Semmelweis u. 6., Szeged, 6725, Hungary.
Dagmar TimmannDepartment of Neurology and Center for Translational Neuro and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany.
Claudia VinciguerraNeurology Unit, University Hospital of Salerno, Salerno, Italy.
Dénes ZádoriDepartment of Neurology, University of Szeged, Semmelweis u. 6., Szeged, 6725, Hungary.
Letizia LeocaniFaculty of Neurology, Vita-Salute San Raffaele University, Via Olgettina 58, 20132, Milan, Italy. leocani.letizia@unisr.it.ORCID http://orcid.org/0000-0001-9326-6753

Funding

Associazione Italiana Sclerosi Multipla 2024/BR/010
6 · The paper itself

Abstract

backgroundRare neurological diseases often present with severe cognitive impairment but face significant challenges in access to specialized care. Telemonitoring and telerehabilitation are promising approaches to improve the standard of care in common neurological diseases and could prove even more beneficial to patients with rare neurological diseases.

aimTo review the available evidence on the usability and validity of cognitive telemonitoring or telerehabilitation in rare neurological diseases.

methodsWe performed a scoping review, examining all studies published in the last 25 years on both synchronous and asynchronous cognitive telemonitoring or telerehabilitation approaches in rare neurological diseases of adulthood.

resultsActive digital cognitive tests show promising feasibility and validity, especially for people with Frontotemporal Dementia and Huntington's Disease. However, methodological limitations remain, notably the high rate of dropouts for active telemonitoring and limited evidence of cognitive domain-specific sensitivity for passive telemonitoring. Cognitive telerehabilitation is emerging as a feasible and potentially effective approach for primary progressive aphasia. However, other rare neurological diseases still require proper investigation, and the available evidence is still largely preliminary, and is plagued by small sample sizes and heterogeneous methodology, which limits generalizability.

conclusionOur review recognizes the promise of remote approaches in expanding access to both cognitive monitoring and rehabilitation for rare neurological diseases but emphasizes the need for rigorously designed trials to establish clinical utility and best practices. Key unmet needs include improvement of adherence to active telemonitoring, evaluation of clinical validity in reference to gold-standard clinical outcome measures for passive telemonitoring, evaluation of clinical utility via longitudinal studies, evaluation of feasibility across a wider range of disease severity, and technological literacy.

Indexed as

Nervous System DiseasesRare DiseasesTelerehabilitationHumansTelemedicineCognitionRare neurological diseasesTelemedicineTelemonitoringTelerehabilitation

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.