Evidence map›Paper›PMID 42260341›Full record

ArticleBMC microbiology2026

Pathogenic signatures and therapeutic evaluation of emergent MPXV Clade Ib in low-susceptibility and immunocompromised mouse models.

Hongyu Han, Xiaowei Wang, Yongchang Wu, Xiaorong Yang, Peng Qian, Xiaoqing Xie, Dongmei Jiang, Shan Wu, Xiaoping Tang, Quanhai Pang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongyu Han *College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030800, China.
Xiaowei Wang *College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030800, China.
Yongchang WuInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China.
Xiaorong YangInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China.
Peng QianInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China.
Xiaoqing XieInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China.
Dongmei JiangInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China.
Shan WuInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China.
Xiaoping TangInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China. tangxp@gzhmu.edu.cn.
Quanhai PangCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030800, China. pangquanhai@126.com.
Haisheng YuInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China. yuhaisheng@gzhmu.edu.cn.

Funding

Key-Area Research and Development Program of Guangdong Province No. 2022B1111020002National Key Research and Development Program of China No. 2022YFC2304800
6 · The paper itself

Abstract

backgroundMonkeypox (Mpox) is a zoonotic disease that threatens global public health. Different clades of monkeypox virus (MPXV) vary in transmissibility and pathogenicity. In 2023, a Clade Ib MPXV variant emerged in the Democratic Republic of the Congo, continued to spread in parts of Africa, and subsequently spilled over to other regions, posing new challenges for outbreak prevention and control.

resultsWe established stable mouse models of MPXV Clade Ib infection by intranasally infecting C57BL/6/STAT1

conclusionWe established reproducible mouse models for MPXV Clade Ib infection and demonstrated that Clade Ib showed greater replication capacity and pathogenicity than Clade IIb in these models. This study also provides a foundation for subsequent research on the pathogenesis of MPXV and the evaluation of antiviral efficacy.

Indexed as

Immunocompromised HostMonkeypox virusMpox, MonkeypoxAnimalsDisease Models, AnimalDisease SusceptibilityFemaleMiceMice, Inbred BALB CMice, Inbred C57BLViral LoadMonkeypox virusMouse modelMpoxMPXV Clade IbPathogenicity

Identifiers

PMID42260341
PMCPMC13471665

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.