ArticleBMC microbiology2026
Comparative effects of viable and gamma-irradiated Bifidobacterium longum subsp. infantis on immune modulation and resistance to furunculosis in rainbow trout (Oncorhynchus mykiss).
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated the effects of dietary supplementation with live (B-PRO) and gamma-irradiated (B-PAR) Bifidobacterium longum subsp. infantis on growth performance, innate immune-related parameters, antioxidant status, and resistance to Aeromonas salmonicida in rainbow trout (Oncorhynchus mykiss).
resultsAfter 60 days of feeding, both B-PRO and B-PAR were associated with improved growth performance, feed utilization, and body composition compared with the control group, with generally higher values in B-PRO. Hematological parameters, including erythrocyte and leukocyte counts, were elevated in treated groups. Innate immune indicators (lysozyme activity, complement C3, and bactericidal activity) and antioxidant status (SOD, GSH-Px, and total antioxidant capacity) were significantly improved, accompanied by reduced malondialdehyde levels. Gene expression analysis showed tissue-dependent modulation of TNF-α, IL-6, and IL-8, indicating a non-uniform immunoregulatory response. Following A. salmonicida challenge, survival was ~95% in both treated groups versus ~15% in controls. Histopathological evaluation indicated reduced tissue damage in supplemented fish.
conclusionsDietary supplementation with both live and gamma-irradiated B. infantis is associated with improved growth, modulation of innate immune-related parameters, enhanced antioxidant capacity, and increased disease resistance in rainbow trout. The comparable effects of both preparations suggest that bacterial viability is not essential for several observed responses under the present conditions. However, mechanistic interpretations remain limited due to the absence of direct assessment of immune signaling pathways.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.