Trial reportDrug design, development and therapy2026
Effect of Intraoperative Low-Dose Lidocaine Administration on the Consumption of Mivacurium During Gynecological Laparoscopic Surgery: A Prospective Clinical Study.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of Intraoperative Low-Dose Lidocaine on Mivacurium Requirement in Gynecological Laparoscopy [Letter].Drug design, development and therapy · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recent literatures have shown that lidocaine obviously shortened the onset time and reduced the maintenance dose of vecuronium. However, there have been no reports on the use of mivacurium. This study aimed to investigate the effects of lidocaine on the requirement and onset time of mivacurium administration during gynecological laparoscopic surgery. Methods: 66 patients scheduled for elective gynecological laparoscopic surgery were randomly assigned to receive an intravenous bolus of 1.5 mg·kg Results: The onset time of mivacurium was significantly shorter in the lidocaine group than in the control group (mean difference -25.0 s, 95% CI -47.8 to -2.3, Conclusion: Intravenously administered lidocaine significantly decreased the requirement of mivacurium, shortened the onset time, accelerated the extubation time, and alleviated pain intensity at 6 h and 12 h after surgery, without increasing adverse events in patients with a low risk of airway difficulty undergoing gynecological laparoscopic surgery. Given the small sample size from a single centre, our result requires further verification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.