ReviewBiotechnology journal2026
The Role of Exosomes in Bone Metastasis and Bone Tissue Engineering: Molecular Mechanisms and Therapeutic Opportunities.
Review in Biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exosomes, nanoscale extracellular vesicles secreted by almost all cell types, have emerged as pivotal mediators of intercellular communication within both pathological and regenerative microenvironments. In bone metastasis, tumor-derived exosomes (TDEs) play a crucial role in the establishment of pre-metastatic niches, modulation of osteoclast-osteoblast balance, and promotion of tumor cell colonization through the transfer of bioactive molecules such as proteins, lipids, and non-coding RNAs. Conversely, in bone tissue engineering, stem cell-derived exosomes have demonstrated remarkable potential to promote osteogenesis, angiogenesis, and tissue regeneration by activating signaling pathways that regulate bone remodeling. This dual role of exosomes-as drivers of disease progression and as therapeutic agents-highlights their significance as both diagnostic biomarkers and next-generation biologics. This review provides a comprehensive overview of the molecular mechanisms underlying exosome-mediated communication in bone metastasis and bone regeneration, summarizes recent advances in exosome-engineered biomaterials, and discusses the translational challenges that must be addressed to enable clinical applications. Understanding the multifaceted functions of exosomes will pave the way for the development of novel exosome-based strategies for the diagnosis and treatment of bone-related diseases.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.