Evidence map›Paper›PMID 42262087›Full record

ArticleJournal of bacteriology2026

A genotoxin associated with colorectal cancer linked to gut dysbiosis in children with cystic fibrosis.

Kaitlyn E Barrack, Sarvesh V Surve, Ana V de Sousa Bezerra, Caitlin E Murphy, Shannon M Soucy, Miguel A Aguilar Ramos, Rebecca A Valls, Rebekah D Ruff, Emily P Balskus, Julie L Sanville and 2 more

Abstract read
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kaitlyn E BarrackDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Sarvesh V SurveDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Ana V de Sousa Bezerra *Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Caitlin E Murphy *Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Shannon M SoucyDepartment of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Miguel A Aguilar RamosDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Rebecca A VallsDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Rebekah D RuffDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0001-5985-5714
Julie L SanvilleDivision of Pediatric Gastroenterology, Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Juliette C MadanDepartment of Psychiatry and Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA.
George A O'TooleDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-2861-4392

Funding

Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI Li Song · 2019 to 2026
$27.2M
Dartmouth Cystic Fibrosis Training ProgramT32HL134598 · NHLBI · DARTMOUTH COLLEGE · PI George A. O'Toole · 2017 to 2026
$1.7M
Arsenic, the Microbiome & Health Outcomes: Mechanisms to Methods of InterventionR01ES033988 · NIEHS · DARTMOUTH COLLEGE · PI George A. O'Toole · 2023 to 2026
$1.6M
NHLBI NIH HHS T32 HL134598NIEHS NIH HHS R01 ES033988NIGMS NIH HHS P20 GM130454
6 · The paper itself

Abstract

Cystic fibrosis (CF) alters the gastrointestinal microbiome from an early age, leading to significant changes in microbial composition and functionality. This study explores the physiological and microbiological factors contributing to dysbiosis in children with cystic fibrosis (cwCF), characterized by an increase in potentially pathogenic

Indexed as

Colorectal NeoplasmsCystic FibrosisDysbiosisGastrointestinal MicrobiomeBacteroidesChildChild, PreschoolColonEscherichia coliFemaleHumansMaleMicrobial InteractionsPeptidesPolyketidescolibactinPeptidesPolyketidescolibactincystic fibrosisdysbiosisgut microbiomephysiology

Identifiers

PMID42262087
PMCPMC13393419

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.