Evidence map›Paper›PMID 42262124›Full record

Trial reportmSystems2026

Reshaping of the fecal proteome and metaproteome in obese patients 2 years after bariatric surgery.

Alessandro Tanca, Laura De Diego, Maria Antonietta Deledda, Flavio De Maio, Cristian Boru, Mario Musella, Marco Raffaelli, Gianfranco Silecchia, Giovanni Delogu, Sergio Uzzau

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro TancaDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.ORCID 0000-0002-6066-7048
Laura De DiegoDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Maria Antonietta DeleddaDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Flavio De MaioDepartment of Laboratory and Hematology Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Cristian BoruDepartment of Medical-Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University "La Sapienza" of Rome, Rome, Italy.
Mario MusellaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy.
Marco RaffaelliDivision of Endocrine and Metabolic Surgery, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Gianfranco SilecchiaDepartment of Medical-Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University "La Sapienza" of Rome, Rome, Italy.
Giovanni DeloguDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Sergio UzzauDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.ORCID 0000-0001-6246-2794

Funding

European Association for Endoscopic Surgery and other Interventional TechniquesMinistero dell'Istruzione, dell'Università e della Ricerca (MIUR) PON04a2_00557Sapienza Università di Roma 2017 Funds
6 · The paper itself

Abstract

Bariatric surgery provides effective and durable weight loss in patients with severe obesity. Both the surgical procedure and postoperative management, including dietary and behavioral changes, are known to induce long-term alterations in gut microbiota composition. However, their impact on microbial and host proteome profiles remains poorly understood. In this prospective, multicenter cohort study, we compared the fecal metaproteome profile of 45 patients with severe obesity at preoperative baseline (T0) and 2 years after surgery (T1). Patients were randomized to receive either Roux-en-Y gastric bypass or one anastomosis gastric bypass. At T1, the relative abundance of the bacterial genera

Indexed as

Bariatric SurgeryFecesGastrointestinal MicrobiomeObesityObesity, MorbidProteomeAdultFemaleHumansMaleMiddle AgedProspective StudiesProteomicsProteomebariatric surgerygut microbiotamass spectrometrymetabolismmetaproteomicsobesityproteomics

Identifiers

PMID42262124
PMCPMC13386881

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.