Evidence map›Paper›PMID 42262433›Full record

ArticleTissue engineering and regenerative medicine2026

Differential Wound Healing Potential of Tonsil Parenchymal and Epithelial Mesenchymal Stromal Cell-Derived Exosomes.

Harry Jung, Hyeonsun Kim, Jihyeon Lee, Hyeon Gyeong Kim, Jae Jun Lee, Kyunghyuk Park, Bukyoung Cha, Sang Hyen Yu, Minji Kim, Sun-Wha Im and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering and regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Harry JungInstitute of New Frontier Research Team, Hallym Clinical and Translation Science Institute, Hallym University, 1, Hallymdaehak-gil, Chuncheon, Gangwon-do, 24252, Republic of Korea.
Hyeonsun KimInstitute of New Frontier Research Team, Hallym Clinical and Translation Science Institute, Hallym University, 1, Hallymdaehak-gil, Chuncheon, Gangwon-do, 24252, Republic of Korea.
Jihyeon LeeInstitute of New Frontier Research Team, Hallym Clinical and Translation Science Institute, Hallym University, 1, Hallymdaehak-gil, Chuncheon, Gangwon-do, 24252, Republic of Korea.
Hyeon Gyeong KimInstitute of New Frontier Research Team, Hallym Clinical and Translation Science Institute, Hallym University, 1, Hallymdaehak-gil, Chuncheon, Gangwon-do, 24252, Republic of Korea.
Jae Jun LeeInstitute of New Frontier Research Team, Hallym Clinical and Translation Science Institute, Hallym University, 1, Hallymdaehak-gil, Chuncheon, Gangwon-do, 24252, Republic of Korea.
Kyunghyuk ParkGenomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, 03080, Republic of Korea.
Bukyoung ChaGenomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, 03080, Republic of Korea.
Sang Hyen YuGenomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, 03080, Republic of Korea.
Minji KimDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, 03080, Republic of Korea.
Sun-Wha ImDepartment of Biochemistry and Molecular Biology, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Ok Joo LeeMicrophysiological Systems Institute, Hallym Clinical and Translation Science Institute, Hallym University, 1, Hallymdaehak-gil, Chuncheon, Gangwon-do, 24252, Republic of Korea.
Hae Sang ParkInstitute of New Frontier Research Team, Hallym Clinical and Translation Science Institute, Hallym University, 1, Hallymdaehak-gil, Chuncheon, Gangwon-do, 24252, Republic of Korea. hs-piao@hanmail.net.ORCID http://orcid.org/0000-0002-5968-2507

Funding

Hallym University Medical Center HURF-2022-48National Research Foundation (Republic of Korea) RS-2023-00223501
6 · The paper itself

Abstract

backgroundThe biological characteristics of mesenchymal stromal cells (MSCs) and their exosomes can vary depending on the tissue layer of origin, potentially influencing their regenerative capacity. This study aimed to determine whether exosomes derived from epithelial (TE-MSCs) and parenchymal (TP-MSCs) layers of human tonsils exhibit distinct therapeutic effects in oral mucositis (OM).

methodsMSCs Were isolated from the epithelial (TE-MSCs) and parenchymal (TP-MSCs) layers of human tonsils. Exosomes were characterized and tested for regenerative and anti-inflammatory effects in vitro and in a 5-FU-induced OM hamster model

resultsBoth TP-MSCs and TE-MSCs exhibited typical MSC phenotypes and multipotency comparable to BMSCs. Transcriptomic profiling revealed distinct layer-specific features, with TE-MSCs enriched in developmental and morphogenetic pathways. TE-MSC-derived exosomes (TE-MSC-Exo) showed enhanced wound closure, downregulation of IL-1β and TNF-α, and selective induction of HGF and ICAM-1 expression. In vivo, TE-MSC-Exo treatment resulted in the smallest mean wound size and most complete re-epithelialization among experimental groups.

conclusionExosomes derived from tonsil MSCs effectively promote epithelial regeneration in OM, with TE-MSC-Exo exhibiting enhanced therapeutic potential. These findings highlight the importance of MSC layer origin in defining exosome function and suggest that TE-MSC-Exo may serve as a promising platform for exosome-based mucosal repair therapies.

Indexed as

Epithelial CellsExosomesMesenchymal Stem CellsPalatine TonsilWound HealingAnimalsCell DifferentiationCricetinaeHumansEpithelial regenerationExosomeHepatocyte growth factor (HGF)Oral mucositisTonsil-derived mesenchymal stromal cells (MSCs)

Identifiers

PMID42262433
PMCPMC13415426

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.