ArticleAnnals of African medicine2026
Activation of the Nuclear Factor Kappa-light-chain-enhancer of Activated B-cells Pathway Induces a Pro-inflammatory Network in Patients with Pulmonary Tuberculosis.
Article in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLeukocyte-stimulating inflammatory cytokines, including interleukin (IL)-27, IL-1β, and IL-10, in conjunction with the transcription factor nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB), are essential in limiting Mycobacterium tuberculosis infections; however, it remains uncertain if these indicators are a reliable indicator of the severity of TB illness. MATERIALS AND
methodsUsing real-time polymerase chain reaction (PCR), we examined the mRNA expression of IL-27, IL-1β, IL-10, and NF-κB in peripheral blood mononuclear cell responses in patients with tuberculosis (TB) ( n = 25).
resultsPCR amplification of 16S specific to mycobacterium DNA showed 84% positivity rate among the 25 samples. Sputum patients with active TB showed higher activation NF-κB mRNA expression when compared to healthy controls. Furthermore, the multidimensional IL-27 secretion in TB patients showed statistically significant mRNA expression as compared to healthy controls. Similarly, TB patients had drastically changed pro-inflammatory cytokine IL-1β mRNA expression. In addition, TB patients' anti-inflammatory cytokine IL-10 mRNA expression was substantially lower than that of healthy controls.
conclusionOur findings highlight significant alterations in cytokine expression (IL-27, IL-1β, and IL-10) and NF-κB activation in active TB patients, indicating their potential roles in TB pathogenesis. However, further research is required to confirm their value as biomarkers for disease severity.
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