Evidence map›Paper›PMID 42263016›Full record

ArticleBiochemistry2026

Backbone Nitrogen Substitution Probes the Role of Glycine Residues at GxxxG Interfaces in Transmembrane Helices.

Diana Thomas, Fengyi Gu, Robert W Newberry

Abstract read
In one paragraph

Article in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Diana ThomasDepartment of Chemistry, The University of Texas at Austin 105 E. 24th Street, Austin, Texas 78712, United States.
Fengyi GuDepartment of Chemistry, The University of Texas at Austin 105 E. 24th Street, Austin, Texas 78712, United States.
Robert W NewberryDepartment of Chemistry, The University of Texas at Austin 105 E. 24th Street, Austin, Texas 78712, United States.ORCID 0000-0002-2020-2641

Funding

CHEMICAL STRATEGIES FOR CONFORMATIONAL CONTROL OF BIOACTIVE PEPTIDESR35GM160477 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Robert William Newberry · 2025 to 2026
$772k
Biophysical Determinants of Physiological and Pathological alpha-Synuclein Membrane InteractionsR00NS116679 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI NEWBERRY, ROBERT WILLIAM · 2022 to 2024
$740k
NIGMS NIH HHS R35 GM160477NINDS NIH HHS R00 NS116679
6 · The paper itself

Abstract

Association of transmembrane helices is central to the structure and function of membrane proteins. A common feature of these interfaces is the GxxxG motif, which allows for close contact between the protein backbones, resulting in the formation of a network of weak hydrogen bonds between C

Indexed as

GlycineGlycophorinsMembrane ProteinsAmino Acid SubstitutionFluorescence Resonance Energy TransferHydrogen BondingLipid BilayersModels, MolecularProtein MultimerizationProtein Structure, SecondaryGlycineGlycophorinsLipid BilayersMembrane Proteins

Identifiers

PMID42263016
PMCPMC13285413

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.