Evidence map›Paper›PMID 42264629›Full record

ReviewJACC. Cardiovascular interventions2026

Current Evidence, Emerging Evidence, and Decision-Making: An Algorithm for Leaflet Modification Procedures.

Adam B Greenbaum, John T D'Angelo, Robert J Lederman, Elsa Hebbo, Kwong-Yue Eric Chan, Ho-On Alston Conrad Chiu, Ole De Backer, Danny Dvir, Phillip Freeman, Patrick T Gleason and 11 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JACC. Cardiovascular interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Adam B GreenbaumStructural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.
John T D'AngeloStructural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.
Robert J LedermanCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Elsa HebboStructural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.
Kwong-Yue Eric ChanCardiology Division, Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Ho-On Alston Conrad ChiuCardiology Division, Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Ole De BackerThe Heart Center, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Danny DvirDepartment of Cardiology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Phillip FreemanKarolinska University Hospital, Stockholm, Sweden.
Patrick T GleasonStructural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA.
David Hildick-SmithSussex Cardiac Centre, University Hospitals Sussex, Brighton, United Kingdom.
Jaffar M KhanSt. Francis Hospital and Heart Center, Roslyn, New York, USA.
Amar KrishnaswamyDepartment of Cardiology, Robert and Suzanne Tomsich Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Cheung-Chi Simon LamCardiology Division, Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Stamatios LerakisMount Sinai Fuster Heart Hospital, New York, New York, USA.
James M McCabeDivision of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Karl PoonThe Prince Charles Hospital, Brisbane, Australia.
Toby RogersSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington, District of Columbia, USA.
Gilbert H L TangMount Sinai Health System, New York, New York, USA.
Mohamed Abdel-WahabDepartment of Structural Heart Disease/Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.
Vasilis C BabaliarosStructural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia, USA. Electronic address: vbabali@emory.edu.

Funding

Novel catheter treatment of valve diseaseZIAHL006040 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2010 to 2025
$23.6M
MRI catheter design and fabricationZIAHL006041 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2014 to 2025
$12.2M
Intramural NIH HHS ZIA HL006040Intramural NIH HHS ZIA HL006041
6 · The paper itself

Abstract

Leaflet modification is a necessary element in the armamentarium of the structural interventionalist and will remain an area of active investment in the future. Although leaflet splitting is proven, there are limitations in certain extreme cases. Although intraleaflet techniques are emerging and potentially have more broad applicability, there remain safety concerns with these techniques. The proposed systematic algorithms on aortic and mitral leaflet modification procedures can serve as a guide to structural operators when selecting the appropriate approach on the basis of anatomy, pathology, and procedural goals.

Indexed as

AlgorithmsAortic ValveClinical Decision-MakingDecision Support TechniquesHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationMitral ValveMitral Valve AnnuloplastyEvidence-Based MedicineHumansProsthesis DesignRisk FactorsTreatment OutcomeBASILICABATMANLAMPOONleaflet modificationUNICORN

Identifiers

PMID42264629
PMCPMC13332340

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.