Evidence map›Paper›PMID 42265050›Full record

ArticleDrug and alcohol review2026

Intranasal Mucosal Atomiser Devices: A Novel Harm Reduction Intervention.

Hayden Green, Thileepan Naren, Brittany Chapman, Martyn Lloyd-Jones, Sione Crawford, Dean Membrey

Abstract readCase Reports
In one paragraph

Article in Drug and alcohol review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hayden GreenCohealth, Melbourne, Australia.ORCID 0000-0002-9244-8587
Thileepan NarenCohealth, Melbourne, Australia.
Brittany ChapmanHarm Reduction Victoria, Melbourne, Australia.
Martyn Lloyd-JonesThe Royal Melbourne Hospital, Melbourne, Australia.
Sione CrawfordHarm Reduction Victoria, Melbourne, Australia.
Dean MembreyCohealth, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFactors associated with diminished peripheral vein access, including age, prolonged history of injecting drug use and coadministration with other substances, are all increasing among people who inject drugs in Australia. This exposes individuals to increased risk of injecting related complications, including skin and soft tissue infection, neurovascular injury and deep vein thrombosis. CASE PRESENTATION: Case 1 is a 48-year-old man with a 30-year history of injecting drug use who presents with recurrent skin and soft tissue infections requiring hospitalisation, surgery and extensive wound care. Case 2 is a 40-year-old woman who has been injecting heroin since her teens, predominantly into the femoral vein. She has developed significant chronic venous insufficiency and severe venous ulcers. Both consumers were motivated to reduce their injecting-related harms and were offered the use of an intranasal atomiser for heroin administration and reported both a positive use experience and an intention to continue to utilise the device. DISCUSSION AND

conclusionsIntranasal administration of heroin via atomising device may be an effective harm reduction intervention. The efficacy of these devices is supported by evaluation within heroin-assisted treatment programs, where they are associated with high rates of treatment retention, a favourable user experience and 50% fewer injection episodes. Harm reduction benefits of these devices require further evaluation but are likely to include reduced rates of infection and overdose. Given the potential benefits, as supported by the two cases reported here, intranasal atomisers should be further evaluated for inclusion within community harm reduction programs.

Indexed as

Harm ReductionHeroinHeroin DependenceNebulizers and VaporizersSubstance Abuse, IntravenousAdministration, IntranasalAdultFemaleHumansMaleMiddle AgedHeroinharm reductioninjecting drug usepeople who use drugs

Identifiers

PMID42265050
PMCPMC13249579

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.