Evidence map›Paper›PMID 42265129›Full record

ReviewNPJ Parkinson's disease2026

Time vortex: the circadian-dopaminergic dialogue in Parkinson's disease.

Meiru Zhou, Yuxiang Xu, Ye Liu, Jing Wang, Keyuan Hou, Zhaowu An, Jianshe Wei

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meiru ZhouInstitute for Brain Sciences Research, Center for Translational Neuromedicine, School of Life Sciences, Henan University, Kaifeng, China.
Yuxiang XuInstitute for Brain Sciences Research, Center for Translational Neuromedicine, School of Life Sciences, Henan University, Kaifeng, China. xuyx@henu.edu.cn.
Ye LiuInstitute for Brain Sciences Research, Center for Translational Neuromedicine, School of Life Sciences, Henan University, Kaifeng, China.
Jing WangInstitute for Brain Sciences Research, Center for Translational Neuromedicine, School of Life Sciences, Henan University, Kaifeng, China.
Keyuan HouInstitute for Brain Sciences Research, Center for Translational Neuromedicine, School of Life Sciences, Henan University, Kaifeng, China.
Zhaowu AnInstitute for Brain Sciences Research, Center for Translational Neuromedicine, School of Life Sciences, Henan University, Kaifeng, China.
Jianshe WeiInstitute for Brain Sciences Research, Center for Translational Neuromedicine, School of Life Sciences, Henan University, Kaifeng, China. jswei@henu.edu.cn.

Funding

Henan Provincial Medical Science and Technology Key Projects Program SBGJ202402075Henan Provincial Science and Technology Key Projects Program 252301420027, 252102311160National Natural Science Foundation of China 81271410, 32161143021
6 · The paper itself

Abstract

Circadian disruption is a prominent non-motor feature of Parkinson's disease (PD) and is bidirectionally linked to PD pathology. It may interact with oxidative stress, inflammation, mitochondrial dysfunction, and proteostasis imbalance, though its causal role remains unclear. Circadian parameters may aid early diagnosis, monitoring, and time-oriented interventions. This review discusses how circadian abnormalities relate to prodromal and clinical PD, related mechanisms, and circadian-based therapies to improve quality of life.

Identifiers

PMID42265129
PMCPMC13590594

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.