ArticleNature genetics2026
Pleiotropic shared heritability quantifies the shared genetic variance of common diseases.
Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The overall contribution of pleiotropy to disease architectures is unknown, as most studies estimate genetic correlations with each auxiliary disease in turn. Here we propose a method-pleiotropic shared heritability with bias correction (PHBC)-to estimate the liability-scale genetic variance of a target disease that is shared with a specific set of auxiliary diseases (
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