ReviewPlanta2026
Prime editing: evolution of CRISPR-Cas system for a robust next-generation genome editing in plants.
Review in Planta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Prime editing is a propulsive and versatile genome engineering technology that enables precise installation of all possible 12 base-to-base conversions, targeted insertions, deletions, and combinatorial modifications without inducing double-strand break (DSB) or requiring exogenous donor DNA template. Since its inception, prime editing has been rapidly adopted across plant systems, offering a powerful platform for functional genomics, trait improvement, and precision molecular breeding. This review comprehensively traces the evolution of prime editors (PEs) from first-generation PE1 to advanced variants such as PE7 and TwinPE. We detail the key technological milestones, including innovations in protein engineering, prime editing guide RNA (pegRNA) architectural improvement, and strategic modulation of host DNA repair mechanisms aimed at enhancing editing efficiency, precision, and versatility. Further, we provide an in-depth overview of plant-adapted prime editing systems, focusing on codon optimization, promoter refinement, pegRNA scaffold engineering, and the integration of plant-compatible Cas9 and reverse transcriptase variants. Special emphasis is given to the application of prime editing in diverse crop species. By consolidating recent advances and highlighting emerging trends, this review presents a forward-looking perspective on the deployment of prime editors (PEs) as transformative tool for precision genome engineering and sustainable crop improvement.
Indexed as
Identifiers
42265375What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.