Evidence map›Paper›PMID 42265429›Full record

ArticleDrug delivery and translational research2026

Hyperbranched poly(β-amino ester)s-mediated delivery of engineered Klotho mRNA rescues senescence and restores cellular homeostasis in aged and Klotho deficient iMSCs.

Syed Aqib Ali Zaidi, Haiyang Yong, Arshad Ahmed Padhiar, Abdullah Faqeer, Jingwei Song, Liangge He, Syed Saqib Ali Zaidi, Nawaz Khan, Dezhong Zhou, Guangqian Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Syed Aqib Ali ZaidiGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Medical School, Shenzhen University, Shenzhen, 518060, China.
Haiyang YongSchool of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Arshad Ahmed PadhiarGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Medical School, Shenzhen University, Shenzhen, 518060, China.
Abdullah FaqeerGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Medical School, Shenzhen University, Shenzhen, 518060, China.
Jingwei SongGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Medical School, Shenzhen University, Shenzhen, 518060, China.
Liangge HeGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Medical School, Shenzhen University, Shenzhen, 518060, China.
Syed Saqib Ali ZaidiGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Medical School, Shenzhen University, Shenzhen, 518060, China.
Nawaz KhanGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Medical School, Shenzhen University, Shenzhen, 518060, China.
Dezhong ZhouSchool of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, 710049, China. Dezhong.zhou@xjtu.edu.cn.
Guangqian ZhouGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Medical School, Shenzhen University, Shenzhen, 518060, China. gqzhou@szu.edu.cn.

Funding

Development and Reform Commission of Shenzhen Municipality Funding for Shenzhen Engineering Laboratory for Orthopedic Diseases and Regenerative TechnologiesNational Natural Science Foundation of China 52473147National Natural Science Foundation of China Grant Nos. 2072480, 32060157, and 32100603
6 · The paper itself

Abstract

A decline in Klotho expression is a defining feature of aging and contributes to cellular dysfunctions. Here, we developed an engineered IVT Klotho mRNA incorporating ARCA capping. Ψ-modification and poly(A) tailing, delivered using a hyperbranched poly(β-amino ester) (HPAE)-based platform to enhance intracellular delivery and translation. Using CRISPR edited KL (-/-) iPSCs and derived iMSCs, we show that loss of KL induces a robust senescent phenotype characterized by activation of p53-p21-p16 pathways, mitochondrial depolarization, elevated ROS, and altered Ca

Indexed as

Anti-agingCellular SenescenceInduced mesenchymal stem cells (iMSCs)KlothomRNA therapyRegenerative therapy

Identifiers

PMID42265429

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.