Evidence map›Paper›PMID 42265503›Full record

ReviewOdontology2026

Biomimetic strategies for the dentin mineralization, using bioactive molecules: a scoping review and bibliometric analysis (2015-2025).

Letícia Martins Pereira, Ranam Moreira Reis, Fábio Dupart Nascimento, Regina Maria Puppin-Rontani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Letícia Martins PereiraDepartamento de Saúde Coletiva, Odontopediatria e Ortodontia, Pediatric Dentistry Division, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Av. Limeira, 901 - Areião, Piracicaba, São Paulo, 13414-903, Brazil.ORCID http://orcid.org/0000-0001-8242-6352
Ranam Moreira ReisDepartamento de Saúde Coletiva, Odontopediatria e Ortodontia, Pediatric Dentistry Division, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Av. Limeira, 901 - Areião, Piracicaba, São Paulo, 13414-903, Brazil.ORCID http://orcid.org/0000-0001-8001-5541
Fábio Dupart NascimentoDepartment of Biochemistry, Molecular Biology division, Federal University of São Paulo - UNIFESP/EPM, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-6672-3373
Regina Maria Puppin-RontaniDepartamento de Saúde Coletiva, Odontopediatria e Ortodontia, Pediatric Dentistry Division, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Av. Limeira, 901 - Areião, Piracicaba, São Paulo, 13414-903, Brazil. rmpuppin@unicamp.br.ORCID http://orcid.org/0000-0002-1218-5159

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The structural collapse of carious dentin, resulting from demineralization, remains a fundamental challenge in restorative dentistry, critically compromising the longevity of adhesive restorations. While conventional remineralization strategies predominantly yield superficial mineralization, they fail to restore the vital intrafibrillar collagen, resulting in mechanically unstable substrates. This scoping review synthesizes evidence from 47 studies (2015-2025) investigating bioactive peptide-based materials for biomimetic dentin regeneration. Our analysis reveals that advances focus on three main pillars: 1. Polymer-induced Liquid-Precursor (PILPs) systems, which use polymeric analogs of non-collagenous protein (e.g., polyaspartic acid) to promote intrafibrillar mineral infiltration and deposition; 2. Self-Assembly Peptides (SAPs) (e.g., P

Indexed as

Biomimetic mineralizationBiomineralizationDentin regenerationPILPSelf-assembly peptidesTissue engineering

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.