Evidence map›Paper›PMID 42265862›Full record

ArticleHLA2026

High-Resolution NGS HLA Typing Identifies Specific Class II-Dominant Risk Haplotypes and HLA LD Structure in Acute Lymphoblastic Leukaemia Among Ethnic Kazakhs.

Zhandos Burkitbayev, Aida Turganbekova, Zhulduz Zhanzakova, Dana Baimukasheva, Zhazira Saduakas, Didara Khamitova, Saniya Abdrakhmanova, Zhaksylyk Masalimov, Wassim Y Almawi

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In one paragraph

Article in HLA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhandos BurkitbayevNational Research Oncology Center, Astana, Kazakhstan.
Aida TurganbekovaScientific and Production Center for Transfusiology, Astana, Kazakhstan.
Zhulduz ZhanzakovaScientific and Production Center for Transfusiology, Astana, Kazakhstan.
Dana BaimukashevaScientific and Production Center for Transfusiology, Astana, Kazakhstan.
Zhazira SaduakasScientific and Production Center for Transfusiology, Astana, Kazakhstan.
Didara KhamitovaScientific and Production Center for Transfusiology, Astana, Kazakhstan.
Saniya AbdrakhmanovaScientific and Production Center for Transfusiology, Astana, Kazakhstan.
Zhaksylyk MasalimovFaculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan.
Wassim Y AlmawiFaculty of Sciences, El-Manar University, El-Manar University Campus at El-Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0003-1633-9757

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lymphoblastic leukaemia (ALL) results from the uncontrolled growth of lymphoid progenitors, yet the immunogenetic factors behind this remain poorly understood. A connection between specific HLA alleles, multi-locus haplotypes and ALL predisposition was suggested, with an ethnic component to this association. This retrospective case-control study analysed 137 ALL cases and 350 ethnically-matched controls using six-digit NGS typing of HLA-A, -B, -C, -DRB1, -DQA1, -DQB1 and -DPB1 loci. Allele and haplotype differences were tested by χ

Indexed as

Genetic Predisposition to DiseaseHaplotypesHistocompatibility Antigens Class IILinkage DisequilibriumPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentAdultAllelesCase-Control StudiesCentral Asian PeopleChildChild, PreschoolEthnicityFemaleGene FrequencyHigh-Throughput Nucleotide SequencingHistocompatibility Antigens Class IIacute lymphoblastic leukaemiahaplotypesHLA polymorphismsKazakhstanlinkage disequilibriumnext‐generation sequencing

Identifiers

PMID42265862
PMCPMC13250375

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.