Evidence map›Paper›PMID 42265922›Full record

ArticleGut microbes2026

Colonic nutritional and physicochemical parameters drive gut microbiota dysbiosis in obesity: what we learned from the Ob-M-ARCOL model development.

Ophélie Uriot, Charlotte Deschamps, Lucie Etienne-Mesmin, Morgane Brun, Mélanie Pouget, Sandrine Chalancon, Claude Durif, Cyril Chaudemanche, Monique Alric, Yves Boirie and 1 more

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ophélie UriotUMR 454 MEDIS, Microbiologie Environnement Digestif et Santé, Université Clermont Auvergne - INRAE, Clermont-Ferrand, France.ORCID 0000-0003-3066-1689
Charlotte DeschampsUMR 454 MEDIS, Microbiologie Environnement Digestif et Santé, Université Clermont Auvergne - INRAE, Clermont-Ferrand, France.ORCID 0000-0002-5461-1195
Lucie Etienne-MesminUMR 454 MEDIS, Microbiologie Environnement Digestif et Santé, Université Clermont Auvergne - INRAE, Clermont-Ferrand, France.ORCID 0000-0001-6104-6043
Morgane BrunUMR 454 MEDIS, Microbiologie Environnement Digestif et Santé, Université Clermont Auvergne - INRAE, Clermont-Ferrand, France.
Mélanie PougetService de Nutrition Clinique, Centre Hospitalo-Universitaire, Clermont-Ferrand, France.ORCID 0000-0002-3972-0262
Sandrine ChalanconUMR 454 MEDIS, Microbiologie Environnement Digestif et Santé, Université Clermont Auvergne - INRAE, Clermont-Ferrand, France.
Claude DurifUMR 454 MEDIS, Microbiologie Environnement Digestif et Santé, Université Clermont Auvergne - INRAE, Clermont-Ferrand, France.
Cyril ChaudemancheGeneral Mills France, Boulogne-Billancourt, France.
Monique AlricUMR 454 MEDIS, Microbiologie Environnement Digestif et Santé, Université Clermont Auvergne - INRAE, Clermont-Ferrand, France.
Yves BoirieService de Nutrition Clinique, Centre Hospitalo-Universitaire, Clermont-Ferrand, France.
Stéphanie Blanquet-DiotUMR 454 MEDIS, Microbiologie Environnement Digestif et Santé, Université Clermont Auvergne - INRAE, Clermont-Ferrand, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity has reached epidemic proportions worldwide with a substantial burden on both individual health and society. Alterations in gut microbiota are increasingly recognized as a key contributor in disease pathogenesis. However, mechanistic understanding at the ecosystem level remains limited. In line with EU and US regulations,

resultsTo address this gap, we performed dietary surveys and conducted an extensive analysis of 250 articles to set-up and validate a unique

conclusionsThese findings highlight the importance of nutritional and physicochemical environment in shaping colonic bacterial and archaeal populations in obesity. This innovative validated model represents a robust and useful platform for mechanistic investigations on gut microbiome in the absence of the host cells, as well as for preclinical evaluation of food and pharmaceutical strategies aiming to restore microbiota eubiosis in a personalized manner.

Indexed as

ColonDysbiosisGastrointestinal MicrobiomeObesityBacteriaFatty Acids, VolatileFecesHumansModels, BiologicalFatty Acids, Volatilebacteriadysbiosisgut microbiotain vitro gut modelmethanogenic ArchaeamucusObesityOb-M-ARCOLshort-chain fatty acid

Identifiers

PMID42265922
PMCPMC13271359

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.