Evidence map›Paper›PMID 42266013›Full record

ArticleThe Kaohsiung journal of medical sciences2026

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia-Reperfusion Injury.

Wei Wang, Xin-Yue Han, Li-An Huang, Yu-Sheng Zhang, Heng Meng, An-Ding Xu

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei WangJinan University, Guangzhou, Guangdong, China.
Xin-Yue HanDepartment of Obstetrics and Gynecology, Shenzhen University General Hospital, Shenzhen, Guangdong, China.
Li-An HuangDepartment of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Yu-Sheng ZhangDepartment of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Heng MengDepartment of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
An-Ding XuDepartment of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0007-5747-1216

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia-reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD-like receptor protein 3 (NLRP3) inflammasome axis. A mouse model of CI/RI was established and treated with TZ alone or in combination with the mitophagy inhibitor Mdivi-1 or the NLRP3 activator nigericin. Neurological function, infarct volume, histopathological changes in the hippocampal CA1 region, mitophagy (Mito-Tracker

Indexed as

cerebral ischemia–reperfusion injurymitophagypyroptosisreactive oxygen species‐NOD‐like receptor protein 3terazosin

Identifiers

PMID42266013
PMCPMC13399670

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.