ArticleInfection and drug resistance2026
Association of TyG with Survival and Metabolic Alterations in Severe Fever with Thrombocytopenia Syndrome: A Single- Centre Retrospective Study.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This single-center retrospective study aimed to assess the correlation between triglyceride-glucose index (TyG) and prognosis in severe fever with thrombocytopenia syndrome (SFTS) and investigate its correlation with metabolic alterations. Methods: A total of 754 patients diagnosed with SFTS at Wuhan Union Hospital between January 2022 and April 2024 were enrolled. 754 SFTS patients were stratified into four groups based on TyG index quartiles. The primary outcome was in-hospital mortality; secondary endpoints included disease severity and secondary infection. Untargeted metabolomics via liquid chromatography-tandem mass spectrometry was conducted to identify significant metabolites and pathways between low and high TyG groups based on the cutoff value of 9.28 among 37 SFTS individuals. Results: SFTS patients with a higher TyG index had significantly worse survival than those with a lower TyG index (HR = 2.53, Conclusion: A high TyG index is significantly associated with increased mortality and risk of secondary infection in SFTS, suggesting a potential role of insulin resistance in the progression of SFTS. The TyG index may serve as a reliable prognostic biomarker for risk stratification in SFTS patients.
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