A DNA Methylation Signature Predicts Survival and Platinum Response in HNSCC.

Riya Chhabra, Alfred Kao, Omar Mokhashi, Wei Tse Li, Daniel John, Jessica Wang-Rodriguez, Weg M Ongkeko

Abstract read

In one paragraph

Article in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Riya ChhabraDepartment of Otolaryngology- Head and Neck Surgery University of California San Diego California USA.ORCID https://orcid.org/0009-0001-3602-9708

Alfred KaoDepartment of Otolaryngology- Head and Neck Surgery University of California San Diego California USA.

Omar MokhashiDepartment of Otolaryngology- Head and Neck Surgery University of California San Diego California USA.

Wei Tse LiDepartment of Otolaryngology- Head and Neck Surgery University of California San Diego California USA.

Daniel JohnDepartment of Otolaryngology- Head and Neck Surgery University of California San Diego California USA.

Jessica Wang-RodriguezDepartment of Pathology University of California San Diego California USA.

Weg M OngkekoDepartment of Otolaryngology- Head and Neck Surgery University of California San Diego California USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: We aimed to develop and validate a DNA methylation-based risk score to identify patients at higher risk of poor survival and platinum non-response. Methods: Genome-wide DNA methylation and clinical data, including treatment response and survival, were analyzed from platinum-treated patients with head and neck squamous cell carcinoma in The Cancer Genome Atlas ( Results: The methylation risk score significantly stratified overall survival (HR = 3.03, 95% CI: 1.20-7.65; Conclusion: A DNA methylation-based risk score stratifies survival and improves prediction of platinum response in head and neck squamous cell carcinoma beyond standard clinical factors. Validation in an oral rinse-based cohort highlights the potential clinical applicability of methylation biomarkers for non-invasive treatment risk stratification and supports prospective evaluation. Level of Evidence: 3.

Indexed as

DNA methylationepigenetic biomarkershead and neck squamous cell carcinomaplatinum‐based chemotherapyprognosistreatment response prediction

Identifiers

PMID42266439

DOI10.1002/lio2.70461

PMCPMC13243778

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.