Evidence mapPaperPMID 42266751Full record

ArticleAmerican journal of cancer research2026

Schisandrin A suppresses hepatocellular carcinoma and sensitizes to sorafenib via modulating retinol metabolism.

Yu Zhou, Yufan Mao, Xueliang Fu, Yanan Li, Meng Xu, Deliang Zhou, Shuai Zha

Abstract read
In one paragraph

Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu ZhouSchool of Laboratory Medicine, Hubei University of Chinese Medicine No. 16 Huangjiahu West Road, Hongshan District, Wuhan 430065, Hubei, PR China.
Yufan MaoSchool of Laboratory Medicine, Hubei University of Chinese Medicine No. 16 Huangjiahu West Road, Hongshan District, Wuhan 430065, Hubei, PR China.
Xueliang FuSchool of Laboratory Medicine, Hubei University of Chinese Medicine No. 16 Huangjiahu West Road, Hongshan District, Wuhan 430065, Hubei, PR China.
Yanan LiHubei Shizhen Laboratory No. 4 Huayuanshan, Wuchang District, Wuhan 430060, Hubei, PR China.
Meng XuDepartment of Traditional Chinese Medicine, Maternal and Child Health Hospital of Hubei Province No. 745 Wuluo Road, Hongshan District, Wuhan 430070, Hubei, PR China.
Deliang ZhouDepartment of General Surgery, Affiliated Hospital of Hubei University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Province Academy of Traditional Chinese Medicine No. 4 Huayuanshan, Wuchang District, Wuhan 430060, Hubei, PR China.
Shuai ZhaSchool of Laboratory Medicine, Hubei University of Chinese Medicine No. 16 Huangjiahu West Road, Hongshan District, Wuhan 430065, Hubei, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is usually diagnosed at an advanced stage, where first-line sorafenib therapy frequently encounters acquired resistance. Natural compounds derived from traditional medicine may provide alternative strategies to address this challenge. Here, we show that Schisandrin A, a lignan from

Indexed as

cell cycle arrestHepatocellular carcinomaretinol metabolismSchisandrin Asorafenib

Identifiers

PMID42266751
PMCPMC13243688

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.