Evidence map›Paper›PMID 42266906›Full record

ReviewThe Lancet regional health. Europe2026

Diagnostic innovation and models of care to improve fibrosis detection and risk stratification in steatotic liver disease.

Nicola Pugliese, Trenton M White, Paul N Brennan, Silvana Pannain, Hannes Hagström, Maurice Michel, Lisa Rice-Duek, Giovanni Targher, Cyrielle Caussy, John F Dillon and 18 more

Abstract readReview
In one paragraph

Review in The Lancet regional health. Europe, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. A global commitment to addressing chronic liver disease.The Lancet regional health. Europe · 2026
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Nicola PuglieseDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Trenton M WhiteBarcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Paul N BrennanDivision of Molecular and Clinical Medicine, University of Dundee, Dundee, Scotland, United Kingdom.
Silvana PannainSection of Endocrinology, Diabetes and Metabolism, University of Chicago Medicine, Chicago, IL, USA.
Hannes HagströmDivision of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden.
Maurice MichelDepartment of Internal Medicine II, University Medical Centre Saarland, Homburg, Germany.
Lisa Rice-DuekBarcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Giovanni TargherMetabolic Diseases Research Unit, IRCCS Sacro Cuore - Don Calabria Hospital, Verona, Italy.
Cyrielle CaussyDépartement Endocrinologie, Diabète et Nutrition, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, Lyon, France.
John F DillonSchool of Medicine, University of Dundee, Dundee, United Kingdom.
Frank TackeDepartment of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany.
Christopher J KopkaBarcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Giada SebastianiDivision of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, Quebec, Canada.
Jerome BoursierUniversitè d'Angers, HIFIH, SFR ICAT, Angers, France.
Emmanuel A TsochatzisUCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London, United Kingdom.
Willem Pieter BrouwerDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Giovanni GuaraldiModena HIV Metabolic Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Roberto VettorDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Maja ThieleCentre for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark.
Michael RodenDepartment of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Norbert StefanDepartment of Internal Medicine IV, Division of Endocrinology, Diabetology, and Nephrology, University of Tübingen, Tübingen, Germany.
Helen JarvisPopulation and Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Pere GinesLiver Unit, Hospital Clínic of Barcelona, Barcelona, Spain.
Jörn M SchattenbergDepartment of Internal Medicine II, University Medical Centre Saarland, Homburg, Germany.
Elisa PoseLiver Unit, Hospital Clínic of Barcelona, Barcelona, Spain.
Stefan ButtigiegDigital Public Health Task Force, Association of Schools of Public Health in the European Region (ASPHER), Brussels, Belgium.
Christopher D ByrneSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Jeffrey V LazarusBarcelona Institute for Global Health (ISGlobal), Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steatotic liver disease (SLD) is the leading cause of chronic liver disease in Europe, with liver fibrosis representing the strongest predictor of liver-related outcomes and an important contributor to cardiometabolic risk. This Series paper examines diagnostic innovation and models of care to improve fibrosis detection and risk stratification across the continuum of care for SLD. A growing range of non-invasive tests for fibrosis assessment is now available, including blood-based biomarkers, imaging modalities, automated laboratory algorithms, and artificial intelligence-enabled tools. However, implementation remains inconsistent because of limited awareness, restricted geographic and financial access to advanced diagnostics, fragmented referral pathways, heterogeneous reimbursement, limited use of automated reflex testing, and poor digital integration across laboratories and electronic health records. Integrated multidisciplinary models of care linking primary care with specialist services may improve early fibrosis detection, referral efficiency, and equitable access to risk-stratified management, particularly among people living with indicator conditions such as type 2 diabetes and obesity.

Indexed as

Blood-based biomarkersDiagnostic innovationDiagnostic pathwaysFibrosis detectionMASLDmetALDModels of careNon-invasive testsPrecision hepatologyRisk stratification

Identifiers

PMID42266906
PMCPMC13245525

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.