ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2026
Sweet or Salty: Comparing Dextrose and Sodium Acetate Umbilical Arterial Catheter Fluids.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate safety and clinical benefit of sodium acetate umbilical arterial catheter (UAC) fluid in neonates.
methodsThis single-center, retrospective cohort study included neonates receiving dextrose 5% or sodium acetate 77 mEq/L heparinized fluid for UAC patency. The primary outcome was the potential number of capillary heel sticks avoided. Secondary outcomes included hypernatremia, intraventricular hemorrhage, metabolic acidosis, acute kidney injury, chronic lung disease, and parenteral nutrition optimization. Subgroup analysis was performed for patients undergoing therapeutic hypothermia and preterm infants.
resultsThere were 202 patients (dextrose n = 100; sodium acetate n = 102) included. The sodium acetate group demonstrated a greater number of potential heel sticks avoided per UAC line day (0 vs 2.2; p < 0.001). Despite a higher incidence of hypernatremia (sodium > 145 mEq/L) with sodium acetate, hypernatremia with sodium > 150 mEq/L were not significant between groups and there were no significant differences in other clinical outcomes.
conclusionsUsing sodium acetate for UAC patency is safe and may decrease the number of painful capillary heel sticks.
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