Evidence map›Paper›PMID 42267117›Full record

ArticleFrontiers in molecular biosciences2026

Vitamin D3 contribution to systemic and local control of

Michela Tarantino, Dorotea Ippolito, Giorgia Barbieri, Paola Petrucci, Alessia Tammaro, Roberta Tassinari, Francesca Maranghi, Emma Michetti, Serena Ammendola, Massimiliano Francia and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michela TarantinoUnit of Emerging Zoonoses, Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Dorotea IppolitoUnit of Emerging Zoonoses, Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Giorgia BarbieriUnit of Emerging Zoonoses, Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Paola PetrucciUnit of Emerging Zoonoses, Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Alessia TammaroUnit of Gender-Specific Prevention and Health, Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Rome, Italy.
Roberta TassinariUnit of Gender-Specific Prevention and Health, Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Rome, Italy.
Francesca MaranghiUnit of Gender-Specific Prevention and Health, Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Rome, Italy.
Emma MichettiDepartment of Biology, Tor Vergata University of Rome, Rome, Italy.
Serena AmmendolaDepartment of Biology, Tor Vergata University of Rome, Rome, Italy.
Massimiliano FranciaUnit of Emerging Zoonoses, Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Rosanna AdoneUnit of Emerging Zoonoses, Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Paolo PasqualiUnit of Emerging Zoonoses, Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Barbara ChirulloUnit of Emerging Zoonoses, Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Vitamin D serves as a critical modulator of innate and adaptive immune responses. Its active metabolite, 1,25-dihydroxyvitamin D3 (1,25(OH) Methods: Employing an in vivo murine model, we recapitulated the systemic and gastrointestinal features of S. Typhimurium-induced acute salmonellosis, which elicits a vigorous pro-inflammatory cytokine response that exacerbates pathogenesis while facilitating bacterial persistence. In this context, we evaluated the therapeutic potential of 1,25(OH) Results: Our findings demonstrate that 1,25(OH) Discussion: These results underscore the immunomodulatory efficacy of vitamin D in combating S. Typhimurium infection and warrant further exploration for clinical translation.

Indexed as

histopathologyimmune responsein vivo modelSalmonella typhimuriumvitamin D3

Identifiers

PMID42267117
PMCPMC13243081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.