Evidence map›Paper›PMID 42267310›Full record

ReviewInternational journal of nanomedicine2026

The Emerging Role of Nanocarrier-Based Delivery Systems for cGAS-STING Activation in Cancer Immunotherapy.

Guanxiong Zhu, Da Li, Hongru Zhang, Jingyuan Wang, Xinyi Li, Liting Zeng, Lingmin Zhang, Lina Yu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guanxiong Zhu *Department of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, People's Republic of China.
Da Li *Department of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, People's Republic of China.
Hongru ZhangDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, People's Republic of China.
Jingyuan WangDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, People's Republic of China.
Xinyi LiDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, People's Republic of China.ORCID 0009-0006-4676-7954
Liting ZengDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, People's Republic of China.
Lingmin ZhangDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, People's Republic of China.ORCID 0000-0002-4215-5401
Lina YuDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of the cGAS-STING pathway is a potential strategy to potentiate anti-tumor immunity. However, clinical translation of STING agonists such as cGAMP is hampered by poor targeting, enzymatic degradation, and systemic off-target toxicity. Nanocarrier-based drug delivery systems (nano-DDS) overcome these limitations by improving stability, bioavailability, and tumor-specific delivery. This review summarizes recent advances in lipid-based, polymeric, metallic, mesoporous silica, and exosomal for STING agonist delivery. These nanoplatforms enable precise drug delivery and controlled release, thereby significantly augmenting anti-tumor immune responses. We further discuss combination strategies of STING nanoagonists with radiotherapy, chemotherapy, phototherapy, and immune checkpoint inhibitors. Finally, we outline current challenges and future directions, including protein corona effects, scalable manufacturing, and personalized therapy.

Indexed as

Drug CarriersDrug Delivery SystemsImmunotherapyMembrane ProteinsNanoparticlesNeoplasmsNucleotidyltransferasesAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansSTING ProteinCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDrug CarriersMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING Proteincancer immunotherapycGAS-STINGimmune activationnanocarrier-based delivery systems

Identifiers

PMID42267310
PMCPMC13244487

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.