SynthesisFrontiers in oral health2026
Crosstalk of the Hippo/YAP pathway in the progression of oral potentially malignant disorders to oral squamous cell carcinoma: a systematic review.
Synthesis in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of this review is to synthesize current evidence on the interaction between Hippo-YAP signaling and EMT in the malignant transformation of oral potentially malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC) and to examine their potential utility as biomarkers and therapeutic targets. Design: Following PRISMA 2020 guidelines, five electronic databases (PubMed, Web of Science, Scopus, LIVIVO, and Embase) were utilized for this search. Eligible studies included human tissue-based investigations and complementary Results: From 2,208 records, 12 studies (26 datasets) were included. Across study designs, Hippo-YAP dysregulation and EMT activation were consistently observed across the normal to OPMD to OSCC progression. YAP nuclear localization correlated with reduced E-cadherin and increased vimentin, N-cadherin, Snail, and Slug expression. Crosstalk between YAP and MAPK/ERK, PI3K/Akt/mTOR, and Wnt/β-catenin pathways further amplified EMT signaling. High
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